Validation of the GenesWell BCT Score in Young Asian Women With HR+/HER2− Early Breast Cancer

• Main Authors: Mi Jeong Kwon, Jai Min Ryu, Soo Youn Cho, Seok Jin Nam, Seok Won Kim, Jeeyeon Lee, Soo Jung Lee, Ji-Young Park, Ho Yong Park, Sungjun Hong, Kyunga Kim, Jinil Han, Youngho Moon, Young Kee Shin, Jeong Eon Lee
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2021-02-01
• Series: Frontiers in Oncology
• Subjects: GenesWell BCT assay; BCT score; prognostic value; predictive value; young breast cancer patients; HR+/HER2− early breast cancer
• Online Access: https://www.frontiersin.org/articles/10.3389/fonc.2021.588728/full

BackgroundThe prognostic or predictive value of commonly used multigene assays in young patients with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2−) early breast cancer is unclear. In this study, we assessed the prognostic value of the GenesWell BCT assay according to age group.MethodsWe identified patients with pN0-1, HR+/HER2− breast cancer in a prospective cohort of women who underwent surgery between 2005 and 2017. The GenesWell BCT assay was performed on tissue samples from selected patients. Distant metastasis-free survival (DMFS) and disease-free survival (DFS) were compared between the risk groups assigned by the BCT score.ResultsA total of 712 patients were eligible for analysis. The median follow-up time was 7.47 years. The BCT score was prognostic in patients aged ≤50 years (n = 404) and those aged >50 years (n = 308). In both age groups, the 10-year DMFS and DFS rates for patients classified as high risk by the BCT score were significantly lower than those for patients classified as low risk. A multivariate analysis revealed that the BCT score was an independent prognostic factor for DFS in patients aged ≤50 years (hazard ratio, 1.28; 95% CI, 1.05–1.56; P = 0.015), as well as those aged >50 years.ConclusionThe BCT score could be used to identify low-risk patients who will not benefit from adjuvant chemotherapy to treat HR+/HER2− early breast cancer regardless of age. A further prospective study to assess the prognostic and predictive value of the BCT score is required.