Pluripotent transcription factors possess distinct roles in normal versus transformed human stem cells.

Pluripotent transcription factors possess distinct roles in normal versus transformed human stem cells.

Cancer and normal stem cells (SCs) share proliferative properties of self-renewal and expression of key transcription factors (TFs). Despite similar TF identities, the functional role of specific TFs responsible for retaining SC state has yet to be examined in cancer.Here, we compare the role of Oct...

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Bibliographic Details
Main Authors: Junfeng Ji, Tamra E Werbowetski-Ogilvie, Bonan Zhong, Seok-Ho Hong, Mickie Bhatia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-11-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2778551?pdf=render

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