The Oligomycin-Sensitivity Conferring Protein of Mitochondrial ATP Synthase: Emerging New Roles in Mitochondrial Pathophysiology

The Oligomycin-Sensitivity Conferring Protein of Mitochondrial ATP Synthase: Emerging New Roles in Mitochondrial Pathophysiology

The oligomycin-sensitivity conferring protein (OSCP) of the mitochondrial FOF1 ATP synthase has long been recognized to be essential for the coupling of proton transport to ATP synthesis. Located on top of the catalytic F1 sector, it makes stable contacts with both F1 and the peripheral stalk, ensur...

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Bibliographic Details
Main Authors: Manuela Antoniel, Valentina Giorgio, Federico Fogolari, Gary D. Glick, Paolo Bernardi, Giovanna Lippe
Format: Article
Language:English
Published: MDPI AG 2014-04-01
Series:International Journal of Molecular Sciences
Subjects:
mitochondria
oligomycin-sensitivity conferring protein (OSCP)
cyclophilin D (CyPD)
FOF1 ATP synthase dimer
permeability transition pore (PTP)
Online Access:http://www.mdpi.com/1422-0067/15/5/7513

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