T-regulatory cells subpopulation in bronchial asthma and heterogeneous phenotypes of chronic obstructive pulmonary disease

T-regulatory cells subpopulation in bronchial asthma and heterogeneous phenotypes of chronic obstructive pulmonary disease

Aim of the study was to investigate the levels of individual subpopulations of T-regulatory (T-reg) cells in patients with different phenotypes of chronic obstructive pulmonary disease (COPD) with moderate bronchial asthma and healthy volunteers. COPD was associated with increased level of natural (...

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Bibliographic Details
Main Authors: N. A. Kirillova, I. A. Deyev, Ye. E. Kremer, L. M. Ogorodova, G. E. Chernogoryuk
Format: Article
Language:English
Published: Siberian State Medical University (Tomsk) 2011-02-01
Series:Bûlleten' Sibirskoj Mediciny
Subjects:
chronic obstructive pulmonary disease
bronchial asthma
copd phenotypes
t-regulatory cells
Online Access:https://bulletin.tomsk.ru/jour/article/view/1314
Description
Summary:Aim of the study was to investigate the levels of individual subpopulations of T-regulatory (T-reg) cells in patients with different phenotypes of chronic obstructive pulmonary disease (COPD) with moderate bronchial asthma and healthy volunteers. COPD was associated with increased level of natural (CD4+CD25high) T-cells, while emphysematous phenotype of disease was associated with the highest pool of natural CD4+CD25high. Bronchial asthma was associated with low levels of inducible (CD4+ FoxP3+ ) T-reg.
ISSN:1682-0363
1819-3684

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