An Alkaloid and a Steroid from the Endophytic Fungus Aspergillus fumigatus

An Alkaloid and a Steroid from the Endophytic Fungus Aspergillus fumigatus

Two new compounds, fumitremorgin 12-methoxy-13-[5'-hydroxy-2'-(1''-hydroxy-3''-methoxy-5''-methylbenzoyl)-3'-methoxy]benzoic acid methyl ester (fumitremorgin D, 1) and 4,8,10,14-tetramethyl-6-acetoxy-14-[16-acetoxy-19-(20,21-dimethyl)-18-ene]-phenanthrene...

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Main Authors: Zizhen Liang, Tiantian Zhang, Xiaoqian Zhang, Jia Zhang, Changqi Zhao
Format: Article
Language:English
Published: MDPI AG 2015-01-01
Series:Molecules
Subjects:
Diphylleia sinensis L
Aspergillus fumigates
indolediketopiperazine alkaloids
steroid
cytotoxicity
Online Access:http://www.mdpi.com/1420-3049/20/1/1424
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spelling doaj-42a19a7902ce48fda029b0c787b81ab02020-11-24T22:53:39ZengMDPI AGMolecules1420-30492015-01-012011424143310.3390/molecules20011424molecules20011424An Alkaloid and a Steroid from the Endophytic Fungus Aspergillus fumigatusZizhen Liang0Tiantian Zhang1Xiaoqian Zhang2Jia Zhang3Changqi Zhao4Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, College of Life Science, Beijing Normal University, Beijing 100875, ChinaKey Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, College of Life Science, Beijing Normal University, Beijing 100875, ChinaKey Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, College of Life Science, Beijing Normal University, Beijing 100875, ChinaKey Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, College of Life Science, Beijing Normal University, Beijing 100875, ChinaKey Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, College of Life Science, Beijing Normal University, Beijing 100875, ChinaTwo new compounds, fumitremorgin 12-methoxy-13-[5'-hydroxy-2'-(1''-hydroxy-3''-methoxy-5''-methylbenzoyl)-3'-methoxy]benzoic acid methyl ester (fumitremorgin D, 1) and 4,8,10,14-tetramethyl-6-acetoxy-14-[16-acetoxy-19-(20,21-dimethyl)-18-ene]-phenanthrene-1-ene-3,7-dione (2) were isolated from the cultured endophytic isolated fungus Aspergillus fumigatus, together with fourteen known compounds. Their structures were elucidated by 1-D and 2-D NMR analyses. The cytotoxicity profile of the compound against the human hepatocellular carcinoma cell line HepG2 was evaluated by MTT antiproliferative assays.http://www.mdpi.com/1420-3049/20/1/1424Diphylleia sinensis LAspergillus fumigatesindolediketopiperazine alkaloidssteroidcytotoxicity
collection DOAJ
language English
format Article
sources DOAJ
author Zizhen Liang
Tiantian Zhang
Xiaoqian Zhang
Jia Zhang
Changqi Zhao
spellingShingle Zizhen Liang
Tiantian Zhang
Xiaoqian Zhang
Jia Zhang
Changqi Zhao
An Alkaloid and a Steroid from the Endophytic Fungus Aspergillus fumigatus
Molecules
Diphylleia sinensis L
Aspergillus fumigates
indolediketopiperazine alkaloids
steroid
cytotoxicity
author_facet Zizhen Liang
Tiantian Zhang
Xiaoqian Zhang
Jia Zhang
Changqi Zhao
author_sort Zizhen Liang
title An Alkaloid and a Steroid from the Endophytic Fungus Aspergillus fumigatus
title_short An Alkaloid and a Steroid from the Endophytic Fungus Aspergillus fumigatus
title_full An Alkaloid and a Steroid from the Endophytic Fungus Aspergillus fumigatus
title_fullStr An Alkaloid and a Steroid from the Endophytic Fungus Aspergillus fumigatus
title_full_unstemmed An Alkaloid and a Steroid from the Endophytic Fungus Aspergillus fumigatus
title_sort alkaloid and a steroid from the endophytic fungus aspergillus fumigatus
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2015-01-01
description Two new compounds, fumitremorgin 12-methoxy-13-[5'-hydroxy-2'-(1''-hydroxy-3''-methoxy-5''-methylbenzoyl)-3'-methoxy]benzoic acid methyl ester (fumitremorgin D, 1) and 4,8,10,14-tetramethyl-6-acetoxy-14-[16-acetoxy-19-(20,21-dimethyl)-18-ene]-phenanthrene-1-ene-3,7-dione (2) were isolated from the cultured endophytic isolated fungus Aspergillus fumigatus, together with fourteen known compounds. Their structures were elucidated by 1-D and 2-D NMR analyses. The cytotoxicity profile of the compound against the human hepatocellular carcinoma cell line HepG2 was evaluated by MTT antiproliferative assays.
topic Diphylleia sinensis L
Aspergillus fumigates
indolediketopiperazine alkaloids
steroid
cytotoxicity
url http://www.mdpi.com/1420-3049/20/1/1424
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AT tiantianzhang analkaloidandasteroidfromtheendophyticfungusaspergillusfumigatus
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AT xiaoqianzhang alkaloidandasteroidfromtheendophyticfungusaspergillusfumigatus
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