3D organoids derived from the small intestine: An emerging tool for drug transport research

3D organoids derived from the small intestine: An emerging tool for drug transport research

Small intestine in vitro models play a crucial role in drug transport research. Although conventional 2D cell culture models, such as Caco-2 monolayer, possess many advantages, they should be interpreted with caution because they have relatively poor physiologically reproducible phenotypes and funct...

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Bibliographic Details
Main Authors: Yuanjin Zhang, Shengbo Huang, Weiguo Zhong, Wenxia Chen, Bingyi Yao, Xin Wang
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Acta Pharmaceutica Sinica B
Subjects:
3D organoid
Small intestine
Drug transporter
Caco-2 cell monolayer
P-glycoprotein
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383520308340

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