Bioactive glycosides from Chinese medicines

• Main Author: Jun Zhou
• Format: Article
• Language: English
• Published: Instituto Oswaldo Cruz, Ministério da Saúde 1991-01-01
• Series: Memórias do Instituto Oswaldo Cruz.
• Subjects: Gastrodia elata; Aconitum austroyunanense; Helicia erratice; Cynanchum otophyllum; Cynanchum atratum; Sweroside from Swertia moleensis; Phlomis betonicoides; Hemostatic saponins from Paris polyphylla; Triterpenoid glycoside from Panax; Siraitia grosvenorii
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600051

Glycosides are the bioactive components of many famous Chinese medicines. Here reported are some bioactive glycosides we discovered from Chinese medicines in recent years. (1) Pheolic glycosides from Chinese medicines: Gastrodia elata, acontium austroynanense and Helicia erratica, three bioactive phenolic glycosides were discovered and two of them have been developed into new drugs. (2) Terpenoidal glycosides: a) Monoterpenoid: the sweroside from Swertia mollensis has been developed intro an anti-hepatitis drug; b) Diterpenoid: Phlomis betonicoides contains sweet glycoides; c) Triterpenoid: many biologically active triterpenoid glycosides were isolated from Panax plants and Siraitia grosvenorii. (3) Steroidal glycosides: a) C21-steroid: Cynanchum otophyllum and C. atratrum contain anti-epilepsy and-tumor glycosides; b) C27-steroid Hemostatic saponins were found in Paris polyphylla.