Lineage commitment of embryonic cells involves MEK1-dependent clearance of pluripotency regulator Ventx2

Lineage commitment of embryonic cells involves MEK1-dependent clearance of pluripotency regulator Ventx2

During early embryogenesis, cells must exit pluripotency and commit to multiple lineages in all germ-layers. How this transition is operated in vivo is poorly understood. Here, we report that MEK1 and the Nanog-related transcription factor Ventx2 coordinate this transition. MEK1 was required to make...

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Bibliographic Details
Main Authors: Pierluigi Scerbo, Leslie Marchal, Laurent Kodjabachian
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-06-01
Series:eLife
Subjects:
pluripotency
xenopus
MEK1
asymmetric division
Ventx
Online Access:https://elifesciences.org/articles/21526

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