MicroRNAs as important contributors in the pathogenesis of colorectal cancer

MicroRNAs as important contributors in the pathogenesis of colorectal cancer

Colorectal cancer (CRC) is the third most fatal and fourth most frequently diagnosed neoplasm in the world. Numerous non-coding RNAs have been shown to contribute in the development of CRC. MicroRNAs (miRNAs) are among the mostly assessed non-coding RNAs in CRC. These transcripts influence expressio...

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Main Authors: Soudeh Ghafouri-Fard, Bashdar Mahmud Hussen, Elham Badrlou, Atefe Abak, Mohammad Taheri
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Biomedicine & Pharmacotherapy
Subjects:
MicroRNA
MiRNA
Colorectal cancer
Biomarker
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221005412
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spelling doaj-428d76d5bc3b4d8fac3c7ca14f307a582021-06-19T04:52:15ZengElsevierBiomedicine & Pharmacotherapy0753-33222021-08-01140111759MicroRNAs as important contributors in the pathogenesis of colorectal cancerSoudeh Ghafouri-Fard0Bashdar Mahmud Hussen1Elham Badrlou2Atefe Abak3Mohammad Taheri4Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, IraqDepartment of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, IranPhytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranSkull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Corresponding author.Colorectal cancer (CRC) is the third most fatal and fourth most frequently diagnosed neoplasm in the world. Numerous non-coding RNAs have been shown to contribute in the development of CRC. MicroRNAs (miRNAs) are among the mostly assessed non-coding RNAs in CRC. These transcripts influence expression and activity of TGF-β, Wnt/β-catenin, MAPK, PI3K/AKT and other CRC-related pathways. In the context of CRC, miRNAs interact with long non-coding RNAs to influence CRC course. Stool and serum levels of miRNAs have been used to distinguish CRC patients from healthy controls, indicating diagnostic roles of these transcripts in CRC. Therapeutic application of miRNAs in CRC has been assessed in animal models, yet has not been verified in clinical settings. In the current review, we have provided a recent update on the role of miRNAs in CRC development as well as diagnostic and prognostic approaches.http://www.sciencedirect.com/science/article/pii/S0753332221005412MicroRNAMiRNAColorectal cancerBiomarker
collection DOAJ
language English
format Article
sources DOAJ
author Soudeh Ghafouri-Fard
Bashdar Mahmud Hussen
Elham Badrlou
Atefe Abak
Mohammad Taheri
spellingShingle Soudeh Ghafouri-Fard
Bashdar Mahmud Hussen
Elham Badrlou
Atefe Abak
Mohammad Taheri
MicroRNAs as important contributors in the pathogenesis of colorectal cancer
Biomedicine & Pharmacotherapy
MicroRNA
MiRNA
Colorectal cancer
Biomarker
author_facet Soudeh Ghafouri-Fard
Bashdar Mahmud Hussen
Elham Badrlou
Atefe Abak
Mohammad Taheri
author_sort Soudeh Ghafouri-Fard
title MicroRNAs as important contributors in the pathogenesis of colorectal cancer
title_short MicroRNAs as important contributors in the pathogenesis of colorectal cancer
title_full MicroRNAs as important contributors in the pathogenesis of colorectal cancer
title_fullStr MicroRNAs as important contributors in the pathogenesis of colorectal cancer
title_full_unstemmed MicroRNAs as important contributors in the pathogenesis of colorectal cancer
title_sort micrornas as important contributors in the pathogenesis of colorectal cancer
publisher Elsevier
series Biomedicine & Pharmacotherapy
issn 0753-3322
publishDate 2021-08-01
description Colorectal cancer (CRC) is the third most fatal and fourth most frequently diagnosed neoplasm in the world. Numerous non-coding RNAs have been shown to contribute in the development of CRC. MicroRNAs (miRNAs) are among the mostly assessed non-coding RNAs in CRC. These transcripts influence expression and activity of TGF-β, Wnt/β-catenin, MAPK, PI3K/AKT and other CRC-related pathways. In the context of CRC, miRNAs interact with long non-coding RNAs to influence CRC course. Stool and serum levels of miRNAs have been used to distinguish CRC patients from healthy controls, indicating diagnostic roles of these transcripts in CRC. Therapeutic application of miRNAs in CRC has been assessed in animal models, yet has not been verified in clinical settings. In the current review, we have provided a recent update on the role of miRNAs in CRC development as well as diagnostic and prognostic approaches.
topic MicroRNA
MiRNA
Colorectal cancer
Biomarker
url http://www.sciencedirect.com/science/article/pii/S0753332221005412
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AT atefeabak micrornasasimportantcontributorsinthepathogenesisofcolorectalcancer
AT mohammadtaheri micrornasasimportantcontributorsinthepathogenesisofcolorectalcancer
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