Disrupting Mitochondrial Electron Transfer Chain Complex I Decreases Immune Checkpoints in Murine and Human Acute Myeloid Leukemic Cells

Disrupting Mitochondrial Electron Transfer Chain Complex I Decreases Immune Checkpoints in Murine and Human Acute Myeloid Leukemic Cells

Oxidative metabolism is crucial for leukemic stem cell (LSC) function and drug resistance in acute myeloid leukemia (AML). Mitochondrial metabolism also affects the immune system and therefore the anti-tumor response. The modulation of oxidative phosphorylation (OxPHOS) has emerged as a promising ap...

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Bibliographic Details
Main Authors: Raquel Luna-Yolba, Justine Marmoiton, Véronique Gigo, Xavier Marechal, Emeline Boet, Ambrine Sahal, Nathalie Alet, Ifat Abramovich, Eyal Gottlieb, Virgile Visentin, Michael R. Paillasse, Jean-Emmanuel Sarry
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
OxPHOS
Immune checkpoints
AML
Online Access:https://www.mdpi.com/2072-6694/13/14/3499

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