A specific tRNA half, 5’tiRNA-His-GTG, responds to hypoxia via the HIF1α/ANG axis and promotes colorectal cancer progression by regulating LATS2

A specific tRNA half, 5’tiRNA-His-GTG, responds to hypoxia via the HIF1α/ANG axis and promotes colorectal cancer progression by regulating LATS2

Abstract Background Currently, tRNA-derived small RNAs (tsRNAs) are recognized as a novel and potential type of non-coding RNAs (ncRNAs), which participate in various cellular processes and play an essential role in cancer progression. However, tsRNAs involvement in colorectal cancer (CRC) progressi...

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Bibliographic Details
Main Authors: En-Wei Tao, Hao-Lian Wang, Wing Yin Cheng, Qian-Qian Liu, Ying-Xuan Chen, Qin-Yan Gao
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Colorectal cancer
Hypoxia
LATS2
Hippo signaling pathway
tRNA half
Online Access:https://doi.org/10.1186/s13046-021-01836-7

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