Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel.

Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel.

The Gloeobacter violaceus ligand-gated ion channel (GLIC) has been extensively studied by X-ray crystallography and other biophysical techniques. This provided key insights into the general gating mechanism of pentameric ligand-gated ion channel (pLGIC) signal transduction. However, the GLIC is acti...

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Bibliographic Details
Main Authors: Ákos Nemecz, Haidai Hu, Zaineb Fourati, Catherine Van Renterghem, Marc Delarue, Pierre-Jean Corringer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-12-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC5760087?pdf=render

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http://europepmc.org/articles/PMC5760087?pdf=render

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