Effect of Different Phospholipids on α-Secretase Activity in the Non-Amyloidogenic Pathway of Alzheimer’s Disease

Effect of Different Phospholipids on α-Secretase Activity in the Non-Amyloidogenic Pathway of Alzheimer’s Disease

Alzheimer’s disease (AD) is characterized by extracellular accumulation of amyloid-β peptide (Aβ), generated by proteolytic processing of the amyloid precursor protein (APP) by β- and γ-secretase. Aβ generation is inhibited when the initial ectodomain shedding is caused by α-secretase, cleaving APP...

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Bibliographic Details
Main Authors: Heike S. Grimm, Tobias Hartmann, Johannes Lehmann, Benjamin Hundsdörfer, Sven Grösgen, Valerie C. Zimmer, Tatjana L. Rothhaar, Viola J. Haupenthal, Marcus O. W. Grimm
Format: Article
Language:English
Published: MDPI AG 2013-03-01
Series:International Journal of Molecular Sciences
Subjects:
Alzheimer’s disease
α-secretase
ADAM10
lipids
phospholipids
chain length
saturation
headgroup
Online Access:http://www.mdpi.com/1422-0067/14/3/5879

Internet

http://www.mdpi.com/1422-0067/14/3/5879

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