Method of autofluorescence diagnostics of skin neoplasms in the near infrared region

We propose a method for the diagnostics of skin neoplasms, based on the analysis of the changes in the autofluorescence spectra in the near infrared range. The autofluorescence was excited by means of the laser radiation with the wavelength 785 nm for ex vivo and in vivo studies with subsequent expo...

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Main Authors:	Yulia A. Khristoforova, Ivan A. Bratchenko, Dmitry N. Artemyev, Oleg O. Myakinin, Sergey V. Kozlov, Alexander A. Moryatov, Valery P. Zakharov
Format:	Article
Language:	English
Published:	Samara National Research University 2015-12-01
Series:	Journal of Biomedical Photonics & Engineering
Subjects:	autofluorescence near IR range dermatology melanoma exponential approximation sensitivity specificity
Online Access:	http://jbpe.ssau.ru/index.php/JBPE/article/view/2887

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spelling	doaj-427b4ec2ad7b47af9a3a6a1efe1d30682020-11-24T21:58:58ZengSamara National Research UniversityJournal of Biomedical Photonics & Engineering2411-28442015-12-011318619210.18287/jbpe-2015-1-3-1862765Method of autofluorescence diagnostics of skin neoplasms in the near infrared regionYulia A. Khristoforova0Ivan A. Bratchenko1Dmitry N. Artemyev2Oleg O. Myakinin3Sergey V. Kozlov4Alexander A. Moryatov5Valery P. Zakharov6Laser and biotechnical systems department, Samara State Aerospace University, RussiaLaser and biotechnical systems department, Samara State Aerospace University, RussiaLaser and biotechnical systems department, Samara State Aerospace University, RussiaLaser and biotechnical systems department, Samara State Aerospace University, RussiaOncology Department, Samara State Medical University, RussiaOncology Department, Samara State Medical University, RussiaLaser and biotechnical systems department, Samara State Aerospace University, RussiaWe propose a method for the diagnostics of skin neoplasms, based on the analysis of the changes in the autofluorescence spectra in the near infrared range. The autofluorescence was excited by means of the laser radiation with the wavelength 785 nm for ex vivo and in vivo studies with subsequent exponential approximation of its spectrum. The quantitative and qualitative criteria for the neoplasm type differentiation by the change of the curvature and the rate of decrease of the approximating curve are found. It is shown that the proposed approach allows the diagnostics of malignant melanomas with the accuracy of 88.4% for ex vivo studies, and 86.2 % for in vivo ones.http://jbpe.ssau.ru/index.php/JBPE/article/view/2887autofluorescencenear IR rangedermatologymelanomaexponential approximationsensitivityspecificity
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yulia A. Khristoforova Ivan A. Bratchenko Dmitry N. Artemyev Oleg O. Myakinin Sergey V. Kozlov Alexander A. Moryatov Valery P. Zakharov
spellingShingle	Yulia A. Khristoforova Ivan A. Bratchenko Dmitry N. Artemyev Oleg O. Myakinin Sergey V. Kozlov Alexander A. Moryatov Valery P. Zakharov Method of autofluorescence diagnostics of skin neoplasms in the near infrared region Journal of Biomedical Photonics & Engineering autofluorescence near IR range dermatology melanoma exponential approximation sensitivity specificity
author_facet	Yulia A. Khristoforova Ivan A. Bratchenko Dmitry N. Artemyev Oleg O. Myakinin Sergey V. Kozlov Alexander A. Moryatov Valery P. Zakharov
author_sort	Yulia A. Khristoforova
title	Method of autofluorescence diagnostics of skin neoplasms in the near infrared region
title_short	Method of autofluorescence diagnostics of skin neoplasms in the near infrared region
title_full	Method of autofluorescence diagnostics of skin neoplasms in the near infrared region
title_fullStr	Method of autofluorescence diagnostics of skin neoplasms in the near infrared region
title_full_unstemmed	Method of autofluorescence diagnostics of skin neoplasms in the near infrared region
title_sort	method of autofluorescence diagnostics of skin neoplasms in the near infrared region
publisher	Samara National Research University
series	Journal of Biomedical Photonics & Engineering
issn	2411-2844
publishDate	2015-12-01
description	We propose a method for the diagnostics of skin neoplasms, based on the analysis of the changes in the autofluorescence spectra in the near infrared range. The autofluorescence was excited by means of the laser radiation with the wavelength 785 nm for ex vivo and in vivo studies with subsequent exponential approximation of its spectrum. The quantitative and qualitative criteria for the neoplasm type differentiation by the change of the curvature and the rate of decrease of the approximating curve are found. It is shown that the proposed approach allows the diagnostics of malignant melanomas with the accuracy of 88.4% for ex vivo studies, and 86.2 % for in vivo ones.
topic	autofluorescence near IR range dermatology melanoma exponential approximation sensitivity specificity
url	http://jbpe.ssau.ru/index.php/JBPE/article/view/2887
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Method of autofluorescence diagnostics of skin neoplasms in the near infrared region

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