Rational mutational analysis of a multidrug MFS transporter CaMdr1p of Candida albicans by employing a membrane environment based computational approach.

Rational mutational analysis of a multidrug MFS transporter CaMdr1p of Candida albicans by employing a membrane environment based computational approach.

CaMdr1p is a multidrug MFS transporter of pathogenic Candida albicans. An over-expression of the gene encoding this protein is linked to clinically encountered azole resistance. In-depth knowledge of the structure and function of CaMdr1p is necessary for an effective design of modulators or inhibito...

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Bibliographic Details
Main Authors: Khyati Kapoor, Mohd Rehan, Ajeeta Kaushiki, Ritu Pasrija, Andrew M Lynn, Rajendra Prasad
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-12-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC2789324?pdf=render

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