GM-CSF Promotes the Expansion and Differentiation of Cord Blood Myeloid-Derived Suppressor Cells, Which Attenuate Xenogeneic Graft-vs.-Host Disease

GM-CSF Promotes the Expansion and Differentiation of Cord Blood Myeloid-Derived Suppressor Cells, Which Attenuate Xenogeneic Graft-vs.-Host Disease

Myeloid-derived suppressor cells (MDSCs) are increased in tumor patients. Studies have shown generation of MDSCs from human peripheral blood mononuclear cells (PBMCs) by various cytokine combinations. However, large scale expansion of human MDSCs has not been demonstrated or applied in clinic settin...

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Bibliographic Details
Main Authors:	Mi-Young Park, Bang-Geul Lim, Su-Yeon Kim, Hyun-Jung Sohn, Sueon Kim, Tai-Gyu Kim
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-02-01
Series:	Frontiers in Immunology
Subjects:	myeloid-derived suppressor cells (MDSCs) umbilical cord blood (CB) CD34+ cells recombinant GM-CSF and SCF cytokine combinations (GM-CSF/SCF) immunosuppressive function xenogeneic graft-vs.-host disease (GVHD)
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2019.00183/full

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