Estradiol levels are elevated in older men with diffuse cutaneous SSc and are associated with decreased survival

Estradiol levels are elevated in older men with diffuse cutaneous SSc and are associated with decreased survival

Abstract Background Systemic sclerosis (SSc) is a female-predominant disease, characterized by excessive extracellular matrix deposition (ECM) with dermal and internal organ fibrosis. Considering the sex-based disparity in disease incidence, estradiol (E2), an estrogen form with pro-fibrotic effects...

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Bibliographic Details
Main Authors: DeAnna Baker Frost, Bethany Wolf, Christine Peoples, Jessica Fike, Katherine Silver, Maureen Laffoon, Thomas A. Medsger, Carol Feghali-Bostwick
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Arthritis Research & Therapy
Subjects:
Systemic sclerosis
Estrogen
Fibrosis
Survival
Online Access:http://link.springer.com/article/10.1186/s13075-019-1870-6

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http://link.springer.com/article/10.1186/s13075-019-1870-6

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