ROMP-Derived cyclooctene-based monolithic polymeric materials reinforced with inorganic nanoparticles for applications in tissue engineering

• Main Authors: Franziska Weichelt, Solvig Lenz, Stefanie Tiede, Ingrid Reinhardt, Bernhard Frerich, Michael R. Buchmeiser
• Format: Article
• Language: English
• Published: Beilstein-Institut 2010-12-01
• Series: Beilstein Journal of Organic Chemistry
• Subjects: hybrid materials; monoliths; nanoparticles; ring-opening metathesis polymerization (ROMP); tissue engineering
• Online Access: https://doi.org/10.3762/bjoc.6.137

Porous monolithic inorganic/polymeric hybrid materials have been prepared via ring-opening metathesis copolymerization starting from a highly polar monomer, i.e., cis-5-cyclooctene-trans-1,2-diol and a 7-oxanorborn-2-ene-derived cross-linker in the presence of porogenic solvents and two types of inorganic nanoparticles (i.e., CaCO3 and calcium hydroxyapatite, respectively) using the third-generation Grubbs initiator RuCl2(Py)2(IMesH2)(CHPh). The physico-chemical properties of the monolithic materials, such as pore size distribution and microhardness were studied with regard to the nanoparticle type and content. Moreover, the reinforced monoliths were tested for the possible use as scaffold materials in tissue engineering, by carrying out cell cultivation experiments with human adipose tissue-derived stromal cells.