An Improved Synthesis of 7, 8-Epoxy-1,3,11-cembratriene-15R(α), 16-diol, a Cembranoid of Marine Origin with a Potent Cancer Chemopreventive Activity

An Improved Synthesis of 7, 8-Epoxy-1,3,11-cembratriene-15R(α), 16-diol, a Cembranoid of Marine Origin with a Potent Cancer Chemopreventive Activity

An effective method for the synthesis of 7,8-epoxy-1,3,11-cembratriene-15R(α), 16-diol and its in vitro Epstein-Barr Virus Early Antigen (EBV-EA) Activation Chemopreventive Assay are reported. This semisynthetic product is a new cembranoid with a potent tumor inhibitory activity that is expected...

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Bibliographic Details
Main Authors: Sherief I. Khalifa, Hesham Fahmy, Jordan K. Zjawiony, Takao Konoshima
Format: Article
Language:English
Published: MDPI AG 2004-02-01
Series:Marine Drugs
Subjects:
cancer chemoprevention
cembranoids
sarcophine
sarcophytol A
EBV-EA activation
Online Access:http://www.mdpi.com/1660-3397/2/1/1/

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