Deep learning improves the ability of sgRNA off-target propensity prediction

Deep learning improves the ability of sgRNA off-target propensity prediction

Abstract Background CRISPR/Cas9 system, as the third-generation genome editing technology, has been widely applied in target gene repair and gene expression regulation. Selection of appropriate sgRNA can improve the on-target knockout efficacy of CRISPR/Cas9 system with high sensitivity and specific...

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Bibliographic Details
Main Authors: Qiaoyue Liu, Xiang Cheng, Gan Liu, Bohao Li, Xiuqin Liu
Format: Article
Language:English
Published: BMC 2020-02-01
Series:BMC Bioinformatics
Subjects:
sgRNA
Off-target
Deep learning
GloVe model
Online Access:https://doi.org/10.1186/s12859-020-3395-z

Internet

https://doi.org/10.1186/s12859-020-3395-z

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