The effect of low-dose ketamine to median cerebral artery's mean flow velocity in patients underwent noncerebral surgery under general anesthesia

• Main Authors: Tjokorda Gde Agung Senapathi, I Putu Pramana Suarjaya, Roy Lizal
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2021-01-01
• Series: Bali Journal of Anesthesiology
• Subjects: cerebral blood flow; intracranial pressure; ketamine; propofol; transcranial doppler
• Online Access: http://www.bjoaonline.com/article.asp?issn=2549-2276;year=2021;volume=5;issue=3;spage=171;epage=173;aulast=Agung

Background: Ketamine can provide sedation and analgesia in specific doses. Whereas most other anesthetic agents exert a suppressive effect on the cardiovascular system and can lower blood pressure, ketamine can have the opposite effect. Although it provides many benefits, the use of ketamine is still limited in patients who are at the risk of increased intracranial pressure, such as head injury and stroke. The present study aims to compare the mean flow velocity-medial cerebral artery's (MFV-MCA) in patients receiving propofol with patients receiving a low-dose combination of propofol and ketamine. Materials and Methods: This was an experimental study with a double-blind, randomized controlled trial design. A total of 58 ASA I-II patients who underwent surgery with general anesthesia technique were collected by the consecutive sampling technique. The sample was divided into two groups: Group A received a low dose of ketamine after the patient was induced with propofol and Group B received NaCl 0.9% after the patient was induced with propofol. We used transcranial Doppler to measure the MFV-MCA before, 5 min after, and 10 min after the administration of ketamine. Results: We found no statistical difference between the groups in terms of MFV-MCA values before ketamine administration (P = 0.908), 5 min after ketamine administration (P = 0.890), and 10 min after ketamine administration (P = 0.981). Conclusion: The administration of low-dose ketamin at 0.3 mg/kg after induction did not increase the MFV-MCA in patients who underwent general anesthesia using propofol.