Sugar or Fat?—Metabolic Requirements for Immunity to Viral Infections
The realization that an intricate link exists between the metabolic state of immune cells and the nature of the elicited immune responses has brought a dramatic evolution to the field of immunology. We will focus on how metabolic reprogramming through the use of glycolysis and fatty-acid oxidation (...
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Frontiers Media S.A.
2017-10-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2017.01311/full |
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doaj-422cda86895e40e39ae714dcace1ba392020-11-24T23:15:50ZengFrontiers Media S.A.Frontiers in Immunology1664-32242017-10-01810.3389/fimmu.2017.01311303850Sugar or Fat?—Metabolic Requirements for Immunity to Viral InfectionsHesham M. Shehata0Andrew J. Murphy1Man kit Sam Lee2Clair M. Gardiner3Suzanne M. Crowe4Suzanne M. Crowe5Shomyseh Sanjabi6David K. Finlay7Clovis Steve Palmer8Clovis Steve Palmer9Clovis Steve Palmer10Virology and Immunology, Gladstone Institutes, San Francisco, CA, United StatesHaematopoiesis and Leukocyte Biology, Baker Heart and Diabetes Institute, Melbourne, VIC, AustraliaHaematopoiesis and Leukocyte Biology, Baker Heart and Diabetes Institute, Melbourne, VIC, AustraliaSchool of Biochemistry and Immunology, Trinity College Dublin, Trinity Biomedical Sciences Institute, Dublin, IrelandCentre for Biomedical Research, Burnet Institute, Melbourne, VIC, AustraliaDepartment of Infectious Diseases, Monash University, Melbourne, VIC, AustraliaVirology and Immunology, Gladstone Institutes, San Francisco, CA, United StatesSchool of Biochemistry and Immunology, Trinity College Dublin, Trinity Biomedical Sciences Institute, Dublin, IrelandCentre for Biomedical Research, Burnet Institute, Melbourne, VIC, AustraliaDepartment of Infectious Diseases, Monash University, Melbourne, VIC, AustraliaDepartment of Microbiology and Immunology, University of Melbourne, Melbourne, VIC, AustraliaThe realization that an intricate link exists between the metabolic state of immune cells and the nature of the elicited immune responses has brought a dramatic evolution to the field of immunology. We will focus on how metabolic reprogramming through the use of glycolysis and fatty-acid oxidation (sugar or fat) regulates the capacity of immune cells to mount robust and effective immune responses. We will also discuss how fine-tuning sugar and fat metabolism may be exploited as a novel immunotherapeutic strategy to fight viral infections or improve vaccine efficacy.http://journal.frontiersin.org/article/10.3389/fimmu.2017.01311/fullimmunometabolismglycolysismTORHIVT cellsviral infection |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Hesham M. Shehata Andrew J. Murphy Man kit Sam Lee Clair M. Gardiner Suzanne M. Crowe Suzanne M. Crowe Shomyseh Sanjabi David K. Finlay Clovis Steve Palmer Clovis Steve Palmer Clovis Steve Palmer |
| spellingShingle |
Hesham M. Shehata Andrew J. Murphy Man kit Sam Lee Clair M. Gardiner Suzanne M. Crowe Suzanne M. Crowe Shomyseh Sanjabi David K. Finlay Clovis Steve Palmer Clovis Steve Palmer Clovis Steve Palmer Sugar or Fat?—Metabolic Requirements for Immunity to Viral Infections Frontiers in Immunology immunometabolism glycolysis mTOR HIV T cells viral infection |
| author_facet |
Hesham M. Shehata Andrew J. Murphy Man kit Sam Lee Clair M. Gardiner Suzanne M. Crowe Suzanne M. Crowe Shomyseh Sanjabi David K. Finlay Clovis Steve Palmer Clovis Steve Palmer Clovis Steve Palmer |
| author_sort |
Hesham M. Shehata |
| title |
Sugar or Fat?—Metabolic Requirements for Immunity to Viral Infections |
| title_short |
Sugar or Fat?—Metabolic Requirements for Immunity to Viral Infections |
| title_full |
Sugar or Fat?—Metabolic Requirements for Immunity to Viral Infections |
| title_fullStr |
Sugar or Fat?—Metabolic Requirements for Immunity to Viral Infections |
| title_full_unstemmed |
Sugar or Fat?—Metabolic Requirements for Immunity to Viral Infections |
| title_sort |
sugar or fat?—metabolic requirements for immunity to viral infections |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Immunology |
| issn |
1664-3224 |
| publishDate |
2017-10-01 |
| description |
The realization that an intricate link exists between the metabolic state of immune cells and the nature of the elicited immune responses has brought a dramatic evolution to the field of immunology. We will focus on how metabolic reprogramming through the use of glycolysis and fatty-acid oxidation (sugar or fat) regulates the capacity of immune cells to mount robust and effective immune responses. We will also discuss how fine-tuning sugar and fat metabolism may be exploited as a novel immunotherapeutic strategy to fight viral infections or improve vaccine efficacy. |
| topic |
immunometabolism glycolysis mTOR HIV T cells viral infection |
| url |
http://journal.frontiersin.org/article/10.3389/fimmu.2017.01311/full |
| work_keys_str_mv |
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