Inactivation of Pmel alters melanosome shape but has only a subtle effect on visible pigmentation.

Inactivation of Pmel alters melanosome shape but has only a subtle effect on visible pigmentation.

PMEL is an amyloidogenic protein that appears to be exclusively expressed in pigment cells and forms intralumenal fibrils within early stage melanosomes upon which eumelanins deposit in later stages. PMEL is well conserved among vertebrates, and allelic variants in several species are associated wit...

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Bibliographic Details
Main Authors: Anders R Hellström, Brenda Watt, Shahrzad Shirazi Fard, Danièle Tenza, Paula Mannström, Kristina Narfström, Björn Ekesten, Shosuke Ito, Kazumasa Wakamatsu, Jimmy Larsson, Mats Ulfendahl, Klas Kullander, Graça Raposo, Susanne Kerje, Finn Hallböök, Michael S Marks, Leif Andersson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-09-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3174228?pdf=render

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