The comparative study of side effect of the two kinds of LD combined oral contraceptive pills containing Norgestimate and Levonorgestrel

• Main Authors: Ghazizade Sh, Nowruzi A
• Format: Article
• Language: fas
• Published: Tehran University of Medical Sciences 1998-05-01
• Series: Tehran University Medical Journal
• Online Access: http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/5822.pdf&manuscript_id=5822

In order to compare the new generation of oral contraceptive pills containing Norgestimate (NGM) with currently available pills containing levonorgestrel (LNG) a clinical trial was conducted. 413 women (age 18-35 years) with no contrainindication to pill use entered the study and randomly received one type of pills. Premenstrual syndrome and depression were significantly decreased in NGM group (P=0.00016, P=0.005), on the other hand, breast tenderness, mood changes and hair loss were significantly increased in LNG group (P=0.001, P=0.042, P=0.011). Comparing two groups with each other, following variables were significantly lower in NGM group: headache (P<0.05), vertigo (P<0.05), cloasma (P<0.05), acne (P<0.04), depression (P<0.05), appetite change (P<0.03). Overall patient satisfaction was similar in two groups.