Dexmedetomidine Protects Rat Liver against Ischemia-Reperfusion Injury Partly by the α2A-Adrenoceptor Subtype and the Mechanism Is Associated with the TLR4/NF-κB Pathway

Dexmedetomidine Protects Rat Liver against Ischemia-Reperfusion Injury Partly by the α2A-Adrenoceptor Subtype and the Mechanism Is Associated with the TLR4/NF-κB Pathway

Toll-like receptor 4 (TLR4)/nuclear factor kappa B (NF-κB) signaling plays a dominant role in the pathogenesis of liver ischemia-reperfusion (IR) injury. Dexmedetomidine (Dex) protects the liver against IR injury via α2-adrenoceptor activation, but the contribution of TLR4 signaling remains unknown....

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Bibliographic Details
Main Authors: Yiheng Wang, Shan Wu, Xiaofang Yu, Shaoli Zhou, Mian Ge, Xinjin Chi, Jun Cai
Format: Article
Language:English
Published: MDPI AG 2016-06-01
Series:International Journal of Molecular Sciences
Subjects:
dexmedetomidine
ischemia-reperfusion injury
liver transplantation
TLR4/NF-κB
α2A-adrenoceptor subtype
Online Access:http://www.mdpi.com/1422-0067/17/7/995

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