Neuroticism is positively associated with leptin/adiponectin ratio, leptin and IL-6 in young adults

Abstract High neuroticism is related to cardiovascular morbidity. Early detection of metabolic and cardiovascular risk is important in high-risk groups to enable preventive measures. The aim of this study was therefore to explore if neuroticism is associated with early biomarkers for cardiovascular...

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Main Authors: Mikaela Syk, Johan Isaksson, Annica J. Rasmusson, Lisa Ekselius, Janet L. Cunningham
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-89251-y
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spelling doaj-41f917db901c48acbe177e42c1aeda092021-05-09T11:32:21ZengNature Publishing GroupScientific Reports2045-23222021-05-0111111010.1038/s41598-021-89251-yNeuroticism is positively associated with leptin/adiponectin ratio, leptin and IL-6 in young adultsMikaela Syk0Johan Isaksson1Annica J. Rasmusson2Lisa Ekselius3Janet L. Cunningham4Department of Neuroscience, Psychiatry, Akademiska sjukhuset, Uppsala UniversityDepartment of Neuroscience, Child and Adolescent Psychiatry, Uppsala UniversityDepartment of Neuroscience, Psychiatry, Akademiska sjukhuset, Uppsala UniversityDepartment of Neuroscience, Psychiatry, Akademiska sjukhuset, Uppsala UniversityDepartment of Neuroscience, Psychiatry, Akademiska sjukhuset, Uppsala UniversityAbstract High neuroticism is related to cardiovascular morbidity. Early detection of metabolic and cardiovascular risk is important in high-risk groups to enable preventive measures. The aim of this study was therefore to explore if neuroticism is associated with early biomarkers for cardiovascular and metabolic disease in young adults from a psychiatry cohort. Blood samples and self-ratings on neuroticism with the Swedish universities Scales of Personality (SSP) questionnaire were collected from 172 psychiatric outpatients and 46 healthy controls. The blood samples were analysed for plasma leptin, adiponectin, CRP, IL-6 and TNF-α. Associations between neuroticism and biomarkers were assessed using Spearman’s correlation coefficients and generalized linear models adjusting for confounders. In the adjusted generalized linear models, neuroticism predicted the leptin/adiponectin ratio (p = 0.003), leptin (p = 0.004) and IL-6 (p = 0.001). These associations were not better explained by current major depressive disorder and/or anxiety disorder. Adiponectin, CRP and TNF-α were not associated with neuroticism. In conclusion, the findings suggest that high neuroticism is related to elevated levels of plasma leptin/adiponectin ratio, leptin and IL-6 in young adults. Young adults with high neuroticism may therefore benefit from preventive interventions to decrease the risk for future metabolic and cardiovascular morbidity, but more research is required to test this hypothesis.https://doi.org/10.1038/s41598-021-89251-y
collection DOAJ
language English
format Article
sources DOAJ
author Mikaela Syk
Johan Isaksson
Annica J. Rasmusson
Lisa Ekselius
Janet L. Cunningham
spellingShingle Mikaela Syk
Johan Isaksson
Annica J. Rasmusson
Lisa Ekselius
Janet L. Cunningham
Neuroticism is positively associated with leptin/adiponectin ratio, leptin and IL-6 in young adults
Scientific Reports
author_facet Mikaela Syk
Johan Isaksson
Annica J. Rasmusson
Lisa Ekselius
Janet L. Cunningham
author_sort Mikaela Syk
title Neuroticism is positively associated with leptin/adiponectin ratio, leptin and IL-6 in young adults
title_short Neuroticism is positively associated with leptin/adiponectin ratio, leptin and IL-6 in young adults
title_full Neuroticism is positively associated with leptin/adiponectin ratio, leptin and IL-6 in young adults
title_fullStr Neuroticism is positively associated with leptin/adiponectin ratio, leptin and IL-6 in young adults
title_full_unstemmed Neuroticism is positively associated with leptin/adiponectin ratio, leptin and IL-6 in young adults
title_sort neuroticism is positively associated with leptin/adiponectin ratio, leptin and il-6 in young adults
publisher Nature Publishing Group
series Scientific Reports
issn 2045-2322
publishDate 2021-05-01
description Abstract High neuroticism is related to cardiovascular morbidity. Early detection of metabolic and cardiovascular risk is important in high-risk groups to enable preventive measures. The aim of this study was therefore to explore if neuroticism is associated with early biomarkers for cardiovascular and metabolic disease in young adults from a psychiatry cohort. Blood samples and self-ratings on neuroticism with the Swedish universities Scales of Personality (SSP) questionnaire were collected from 172 psychiatric outpatients and 46 healthy controls. The blood samples were analysed for plasma leptin, adiponectin, CRP, IL-6 and TNF-α. Associations between neuroticism and biomarkers were assessed using Spearman’s correlation coefficients and generalized linear models adjusting for confounders. In the adjusted generalized linear models, neuroticism predicted the leptin/adiponectin ratio (p = 0.003), leptin (p = 0.004) and IL-6 (p = 0.001). These associations were not better explained by current major depressive disorder and/or anxiety disorder. Adiponectin, CRP and TNF-α were not associated with neuroticism. In conclusion, the findings suggest that high neuroticism is related to elevated levels of plasma leptin/adiponectin ratio, leptin and IL-6 in young adults. Young adults with high neuroticism may therefore benefit from preventive interventions to decrease the risk for future metabolic and cardiovascular morbidity, but more research is required to test this hypothesis.
url https://doi.org/10.1038/s41598-021-89251-y
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