mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system

mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system

Injured mature CNS axons do not regenerate in mammals. Deletion of PTEN, the negative regulator of PI3K, induces CNS axon regeneration through the activation of PI3K-mTOR signaling. We have conducted an extensive molecular dissection of the cross-regulating mechanisms in axon regeneration that invol...

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Bibliographic Details
Main Authors: Linqing Miao, Liu Yang, Haoliang Huang, Feisi Liang, Chen Ling, Yang Hu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-03-01
Series:eLife
Subjects:
axon regeneration
AKT
mTORC1
mTORC2
GSK3
optic nerve
Online Access:https://elifesciences.org/articles/14908

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