MONITORING THE RESISTANCE OF CLINICAL STRAINS OF CANDIDA YEAST TO FLUCONAZOLE (A BRIEF LITERATURE REVIEW)

• Main Author: T. M. Zheltikova
• Format: Article
• Language: Russian
• Published: Remedium Group LLC 2017-12-01
• Series: Медицинский совет
• Subjects: candidiasis; candida; fluconazole; voriconazole; resistance
• Online Access: https://www.med-sovet.pro/jour/article/view/1726
• ISSN: 2079-701X; 2658-5790

The article analyzes the global and national research on the resistance of Candida yeasts to fluconazole. The studies demonstrate that the formation of resistance is determined by many factors: type of yeast, choice of the antimycotic medication, geographical location, etc. In addition, one can not disregard the socio-economic and even political causes. The frequency of detection of drug-resistant strains of different species of Candida yeast to fluconazole varies across different regions, between countries of the same region, and may vary from year to year within a country. In other words, the formation of yeast resistance/ susceptibility to fluconazole, and to other antifungals alike, is dynamic and may be reversible.Therefore, both global and national studies conducted over the past decades and devoted to the formation of resistance of Candida yeast to azoles, in particular, fluconazole, have shown that it is still the medication of choice for the treatment of candidiasis, including acute vulvovaginal candidiasis, as well as for relief and prevention of exacerbations of recurrent vulvovaginal candidiasis. C. krusei was and remains one of the most fluconazole-resistant yeast species. Other species, such as C. inconspicua and C. norvegensis, the number and incidence of which is too low for the moment to make any statistically valid conclusions, may in the future be added to the list.