A Short Report on the Lack of a Pyrogenic Response of Australian Genomic Group IV Isolates of Coxiella burnetii in Guinea Pigs

This small study reports on a non-pyrogenic response of five different Australian isolates of Coxiella burnetii (C. burnetii). They were all members of Genomic Group IV and obtained from three cases of acute human infection, one case of chronic human infection a...

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Main Authors:	Aminul Islam, John Stenos, Gemma Vincent, Stephen Graves
Format:	Article
Language:	English
Published:	MDPI AG 2019-01-01
Series:	Tropical Medicine and Infectious Disease
Subjects:	<i>C. burnetii</i> Q fever Australia pyrogenicity guinea pigs
Online Access:	https://www.mdpi.com/2414-6366/4/1/18

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spelling	doaj-41e33d6d8be64bcd9ff3e1a8b5318deb2020-11-25T01:51:36ZengMDPI AGTropical Medicine and Infectious Disease2414-63662019-01-01411810.3390/tropicalmed4010018tropicalmed4010018A Short Report on the Lack of a Pyrogenic Response of Australian Genomic Group IV Isolates of <i>Coxiella burnetii</i> in Guinea PigsAminul Islam0John Stenos1Gemma Vincent2Stephen Graves3Australian Rickettsial Reference Laboratory, University Hospital Geelong, Geelong, VIC 3220, AustraliaAustralian Rickettsial Reference Laboratory, University Hospital Geelong, Geelong, VIC 3220, AustraliaAustralian Rickettsial Reference Laboratory, University Hospital Geelong, Geelong, VIC 3220, AustraliaAustralian Rickettsial Reference Laboratory, University Hospital Geelong, Geelong, VIC 3220, AustraliaThis small study reports on a non-pyrogenic response of five different Australian isolates of <i>Coxiella burnetii</i> (<i>C. burnetii</i>). They were all members of Genomic Group IV and obtained from three cases of acute human infection, one case of chronic human infection and one case of goat abortion. The guinea pigs infected with these isolates did not develop fever (temperature ≥ 40.0 °C), which is consistent with other members of this genomic group that were isolated from elsewhere in the world. In contrast, guinea pigs infected with the classical USA tick isolate, Nine Mile phase 1 (RSA 493) of Genomic Group I, experienced a four-day febrile period.https://www.mdpi.com/2414-6366/4/1/18<i>C. burnetii</i>Q feverAustraliapyrogenicityguinea pigs
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Aminul Islam John Stenos Gemma Vincent Stephen Graves
spellingShingle	Aminul Islam John Stenos Gemma Vincent Stephen Graves A Short Report on the Lack of a Pyrogenic Response of Australian Genomic Group IV Isolates of <i>Coxiella burnetii</i> in Guinea Pigs Tropical Medicine and Infectious Disease <i>C. burnetii</i> Q fever Australia pyrogenicity guinea pigs
author_facet	Aminul Islam John Stenos Gemma Vincent Stephen Graves
author_sort	Aminul Islam
title	A Short Report on the Lack of a Pyrogenic Response of Australian Genomic Group IV Isolates of <i>Coxiella burnetii</i> in Guinea Pigs
title_short	A Short Report on the Lack of a Pyrogenic Response of Australian Genomic Group IV Isolates of <i>Coxiella burnetii</i> in Guinea Pigs
title_full	A Short Report on the Lack of a Pyrogenic Response of Australian Genomic Group IV Isolates of <i>Coxiella burnetii</i> in Guinea Pigs
title_fullStr	A Short Report on the Lack of a Pyrogenic Response of Australian Genomic Group IV Isolates of <i>Coxiella burnetii</i> in Guinea Pigs
title_full_unstemmed	A Short Report on the Lack of a Pyrogenic Response of Australian Genomic Group IV Isolates of <i>Coxiella burnetii</i> in Guinea Pigs
title_sort	short report on the lack of a pyrogenic response of australian genomic group iv isolates of <i>coxiella burnetii</i> in guinea pigs
publisher	MDPI AG
series	Tropical Medicine and Infectious Disease
issn	2414-6366
publishDate	2019-01-01
description	This small study reports on a non-pyrogenic response of five different Australian isolates of <i>Coxiella burnetii</i> (<i>C. burnetii</i>). They were all members of Genomic Group IV and obtained from three cases of acute human infection, one case of chronic human infection and one case of goat abortion. The guinea pigs infected with these isolates did not develop fever (temperature ≥ 40.0 °C), which is consistent with other members of this genomic group that were isolated from elsewhere in the world. In contrast, guinea pigs infected with the classical USA tick isolate, Nine Mile phase 1 (RSA 493) of Genomic Group I, experienced a four-day febrile period.
topic	<i>C. burnetii</i> Q fever Australia pyrogenicity guinea pigs
url	https://www.mdpi.com/2414-6366/4/1/18
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A Short Report on the Lack of a Pyrogenic Response of Australian Genomic Group IV Isolates of <i>Coxiella burnetii</i> in Guinea Pigs

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