A Short Report on the Lack of a Pyrogenic Response of Australian Genomic Group IV Isolates of <i>Coxiella burnetii</i> in Guinea Pigs

A Short Report on the Lack of a Pyrogenic Response of Australian Genomic Group IV Isolates of <i>Coxiella burnetii</i> in Guinea Pigs

This small study reports on a non-pyrogenic response of five different Australian isolates of <i>Coxiella burnetii</i> (<i>C. burnetii</i>). They were all members of Genomic Group IV and obtained from three cases of acute human infection, one case of chronic human infection a...

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Bibliographic Details
Main Authors: Aminul Islam, John Stenos, Gemma Vincent, Stephen Graves
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Tropical Medicine and Infectious Disease
Subjects:
<i>C. burnetii</i>
Q fever
Australia
pyrogenicity
guinea pigs
Online Access:https://www.mdpi.com/2414-6366/4/1/18
Description
Summary:This small study reports on a non-pyrogenic response of five different Australian isolates of <i>Coxiella burnetii</i> (<i>C. burnetii</i>). They were all members of Genomic Group IV and obtained from three cases of acute human infection, one case of chronic human infection and one case of goat abortion. The guinea pigs infected with these isolates did not develop fever (temperature &#8805; 40.0 &#176;C), which is consistent with other members of this genomic group that were isolated from elsewhere in the world. In contrast, guinea pigs infected with the classical USA tick isolate, Nine Mile phase 1 (RSA 493) of Genomic Group I, experienced a four-day febrile period.
ISSN:2414-6366

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