Mice lacking Ras-GRF1 show contextual fear conditioning but not spatial memory impairments: convergent evidence from two independently generated mouse mutant lines

Mice lacking Ras-GRF1 show contextual fear conditioning but not spatial memory impairments: convergent evidence from two independently generated mouse mutant lines

Ras-GRF1 is a neuronal specific guanine exchange factor that, once activated by both ionotropic and metabotropic neurotransmitter receptors, can stimulate Ras proteins, leading to long-term phosphorylation of downstream signaling. The two available reports on the behavior of two independently genera...

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Bibliographic Details
Main Authors: Raffaele ed'Isa, Steven J Clapcote, Vootele eVoikar, David P Wolfer, Peter eGiese, Riccardo eBrambilla, Stefania eFasano
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-12-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Body Weight
ras-GRF1
Fear conditioning
spatial memory
Intellicage
Ras-ERK
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2011.00078/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnbeh.2011.00078/full

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