Systematic curation of miRBase annotation using integrated small RNA high-throughput sequencing data for C. elegans and Drosophila

MicroRNAs (miRNAs) are a class of 20 to 23 nucleotide small RNAs that regulate gene expression post-transcriptionally in animals and plants. Annotation of miRNAs by the miRBase database has largely relied on computational approaches. As a result, many miRBase entries lack experimental validation, an...

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Bibliographic Details
Main Authors: Xiangfeng eWang, Shirley eLiu
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-05-01
Series:Frontiers in Genetics
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2011.00025/full