Helicobacter hepaticus infection promotes hepatitis and preneoplastic foci in farnesoid X receptor (FXR) deficient mice.

Helicobacter hepaticus infection promotes hepatitis and preneoplastic foci in farnesoid X receptor (FXR) deficient mice.

Farnesoid X receptor (FXR) is a nuclear receptor that regulates bile acid metabolism and transport. Mice lacking expression of FXR (FXR KO) have a high incidence of foci of cellular alterations (FCA) and liver tumors. Here, we report that Helicobacter hepaticus infection is necessary for the develop...

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Bibliographic Details
Main Authors: Alton G Swennes, Alexander Sheh, Nicola M A Parry, Sureshkumar Muthupalani, Kvin Lertpiriyapong, Alexis García, James G Fox
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4153687?pdf=render

Internet

http://europepmc.org/articles/PMC4153687?pdf=render

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