The Role of TROP2 in BCC and Cutaneous SCC: A Clinical and Immunohistochemical Study

• Main Authors: Farag AGA, El-Rebey HS, El-Moneim Shoeib MA, Ahmed El-Fiky SM, Elshaib ME, Mostafa AF
• Format: Article
• Language: English
• Published: Dove Medical Press 2021-06-01
• Series: Clinical, Cosmetic and Investigational Dermatology
• Subjects: bcc; scc; trop2; clinical; immunehistochemical.
• Online Access: https://www.dovepress.com/the-role-of-trop2-in-bcc-and-cutaneous-scc-a-clinical-and-immunohistoc-peer-reviewed-fulltext-article-CCID

Azza Gaber Antar Farag,1 Hala Said El-Rebey,2 Mohamed Abd El-Moneim Shoeib,1 Shimaa Mohammed Ahmed El-Fiky,3 Mustafa Elsayed Elshaib,4 Amal Farid Mostafa2 1Dermatology, Andrology and STDs Department, Faculty of Medicine, Menoufia University, Shebin ElKom, Egypt; 2Pathology Department, Faculty of Medicine, Menoufia University, Shebin ElKom, Egypt; 3Department of Dermatology, Ministry of Health, AlMahala General Hospital, Shebin ElKom, Egypt; 4Faculty of Medicine, Menoufia University, Shebin ElKom, EgyptCorrespondence: Azza Gaber Antar FaragDermatology, Andrology and STDs Department, Faculty of Medicine, Menoufia University, Al-Menoufia, Gamal AbdElnasser Street, 3251, Shebin ElKom, 32511, EgyptTel [phone]Fax [phone]Email [e-mail]: Nonmelanoma skin cancer (NMSC) mainly includes basal (BCC) and squamous (SCC) cell carcinoma. Trophoblast cell-surface antigen2 (TROP2), a cell–signal transduction, is one of the tumor-related calcium signal transducer gene family. TROP2 was highly expressed in many cancers, however, its role in BCC and SCC has not yet been studied.Objective: To investigate TROP2 immunohistochemical expression in BCC and SCC (lesional and peri-lesional) skin compared to controls and correlates its expression with the clinicopathologic parameters of the studied cases.Methods: This case–control study included 17 BCC and 15 SCC patients as well as 12 age and sex matched controls. History and clinical examination were completed. Histological examination of skin biopsies was done together with TROP2 immune-staining.Results: In the studied BCC and SCC cases, there was a significant stepwise up-regulation of TROP2 H score from control to peri-lesional, ended by lesional epidermis in one hand (p=0.003 for BCC and p< 0.001 for SCC) and tumor island in another hand (p=0.001 for BCC and p=0.003 for SCC). TROP2 expression in both BCC and SCC tumor tissues was not affected by any of the studied clinicopathological parameters of the investigated cases.Conclusion: TROP2 could have an important role in BCC and SCC pathogenesis. TROP2 targeting may have appraising effect in clinical application in BCC and SCC management.Keywords: BCC, SCC, TROP2, clinical, immunohistochemical