LYG1 Deficiency Attenuates the Severity of Acute Graft-Versus-Host Disease via Skewing Allogeneic T Cells Polarization Towards Treg Cells

LYG1 Deficiency Attenuates the Severity of Acute Graft-Versus-Host Disease via Skewing Allogeneic T Cells Polarization Towards Treg Cells

Acute graft-versus-host disease (aGVHD) is a lethal complication after allogeneic hematopoietic stem cell transplantation. The mechanism involves the recognition of host antigens by donor-derived T cells which induces augmented response of alloreactive T cells. In this study, we characterized the ro...

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Bibliographic Details
Main Authors: Huihui Liu, Zhengyu Yu, Bo Tang, Shengchao Miao, Chenchen Qin, Yuan Li, Zeyin Liang, Yongjin Shi, Yang Zhang, Qingya Wang, Miao Yan, Zhengyang Song, Hanyun Ren, Yujun Dong
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
LYG1
aGVHD
allogeneic CD4+ T cells
alloreactivity
Th1 cells
Treg cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.647894/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.647894/full

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