Multi-scale cellular engineering: From molecules to organ-on-a-chip

Recent technological advances in cellular and molecular engineering have provided new insights into biology and enabled the design, manufacturing, and manipulation of complex living systems. Here, we summarize the state of advances at the molecular, cellular, and multi-cellular levels using experime...

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Main Authors:	Ngan F. Huang, Ovijit Chaudhuri, Patrick Cahan, Aijun Wang, Adam J. Engler, Yingxiao Wang, Sanjay Kumar, Ali Khademhosseini, Song Li
Format:	Article
Language:	English
Published:	AIP Publishing LLC 2020-03-01
Series:	APL Bioengineering
Online Access:	http://dx.doi.org/10.1063/1.5129788

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spelling	doaj-41d100e6f8a74d40aaf75fe4bb4c153f2020-11-25T02:13:22ZengAIP Publishing LLCAPL Bioengineering2473-28772020-03-0141010906010906-1010.1063/1.5129788Multi-scale cellular engineering: From molecules to organ-on-a-chipNgan F. Huang0Ovijit Chaudhuri1Patrick Cahan2Aijun Wang3Adam J. Engler4Yingxiao Wang5Sanjay Kumar6Ali Khademhosseini7Song Li8 Department of Cardiothoracic Surgery, Stanford University, Stanford, California 94305, USA Department of Mechanical Engineering, Stanford University, Stanford, California 94305, USA Department of Biomedical Engineering, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA Department of Surgery, School of Medicine, University of California Davis, Sacramento, California 95817, USA Department of Bioengineering, Jacob School of Engineering, University of California San Diego, La Jolla, California 92093, USA Department of Bioengineering, Jacob School of Engineering, University of California San Diego, La Jolla, California 92093, USA Department of Bioengineering, University of California Berkeley, Berkeley, California 94720, USA Department of Bioengineering, University of California, Los Angeles, California 90095, USA Department of Bioengineering, University of California, Los Angeles, California 90095, USARecent technological advances in cellular and molecular engineering have provided new insights into biology and enabled the design, manufacturing, and manipulation of complex living systems. Here, we summarize the state of advances at the molecular, cellular, and multi-cellular levels using experimental and computational tools. The areas of focus include intrinsically disordered proteins, synthetic proteins, spatiotemporally dynamic extracellular matrices, organ-on-a-chip approaches, and computational modeling, which all have tremendous potential for advancing fundamental and translational science. Perspectives on the current limitations and future directions are also described, with the goal of stimulating interest to overcome these hurdles using multi-disciplinary approaches.http://dx.doi.org/10.1063/1.5129788
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ngan F. Huang Ovijit Chaudhuri Patrick Cahan Aijun Wang Adam J. Engler Yingxiao Wang Sanjay Kumar Ali Khademhosseini Song Li
spellingShingle	Ngan F. Huang Ovijit Chaudhuri Patrick Cahan Aijun Wang Adam J. Engler Yingxiao Wang Sanjay Kumar Ali Khademhosseini Song Li Multi-scale cellular engineering: From molecules to organ-on-a-chip APL Bioengineering
author_facet	Ngan F. Huang Ovijit Chaudhuri Patrick Cahan Aijun Wang Adam J. Engler Yingxiao Wang Sanjay Kumar Ali Khademhosseini Song Li
author_sort	Ngan F. Huang
title	Multi-scale cellular engineering: From molecules to organ-on-a-chip
title_short	Multi-scale cellular engineering: From molecules to organ-on-a-chip
title_full	Multi-scale cellular engineering: From molecules to organ-on-a-chip
title_fullStr	Multi-scale cellular engineering: From molecules to organ-on-a-chip
title_full_unstemmed	Multi-scale cellular engineering: From molecules to organ-on-a-chip
title_sort	multi-scale cellular engineering: from molecules to organ-on-a-chip
publisher	AIP Publishing LLC
series	APL Bioengineering
issn	2473-2877
publishDate	2020-03-01
description	Recent technological advances in cellular and molecular engineering have provided new insights into biology and enabled the design, manufacturing, and manipulation of complex living systems. Here, we summarize the state of advances at the molecular, cellular, and multi-cellular levels using experimental and computational tools. The areas of focus include intrinsically disordered proteins, synthetic proteins, spatiotemporally dynamic extracellular matrices, organ-on-a-chip approaches, and computational modeling, which all have tremendous potential for advancing fundamental and translational science. Perspectives on the current limitations and future directions are also described, with the goal of stimulating interest to overcome these hurdles using multi-disciplinary approaches.
url	http://dx.doi.org/10.1063/1.5129788
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Multi-scale cellular engineering: From molecules to organ-on-a-chip

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