Enzyme-Mediated Ring-Opening Polymerization of Pentadecalactone to Obtain Biodegradable Polymer for Fabrication of Scaffolds for Bone Tissue Engineering

Enzyme-Mediated Ring-Opening Polymerization of Pentadecalactone to Obtain Biodegradable Polymer for Fabrication of Scaffolds for Bone Tissue Engineering

The optimization of enzyme-mediated polymerization of pentadecalactone (PDL) was performed to obtain macromolecular products suitable for generation of 3D cell supports (scaffolds) for bone tissue engineering. Such parameters as temperature, monomer/enzyme ratio, and monomer concentration were studi...

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Main Authors: V. A. Korzhikov, K. V. Gusevskaya, E. N. Litvinchuk, E. G. Vlakh, T. B. Tennikova
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:International Journal of Polymer Science
Online Access:http://dx.doi.org/10.1155/2013/476748
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spelling doaj-41caf72c50334c4fb5782a7c3fe611692020-11-24T21:57:35ZengHindawi LimitedInternational Journal of Polymer Science1687-94221687-94302013-01-01201310.1155/2013/476748476748Enzyme-Mediated Ring-Opening Polymerization of Pentadecalactone to Obtain Biodegradable Polymer for Fabrication of Scaffolds for Bone Tissue EngineeringV. A. Korzhikov0K. V. Gusevskaya1E. N. Litvinchuk2E. G. Vlakh3T. B. Tennikova4Institute of Macromolecular Compounds RAS Bolshoy Prospect 31, Saint Petersburg 199004, RussiaInstitute of Macromolecular Compounds RAS Bolshoy Prospect 31, Saint Petersburg 199004, RussiaInstitute of Macromolecular Compounds RAS Bolshoy Prospect 31, Saint Petersburg 199004, RussiaInstitute of Macromolecular Compounds RAS Bolshoy Prospect 31, Saint Petersburg 199004, RussiaInstitute of Macromolecular Compounds RAS Bolshoy Prospect 31, Saint Petersburg 199004, RussiaThe optimization of enzyme-mediated polymerization of pentadecalactone (PDL) was performed to obtain macromolecular products suitable for generation of 3D cell supports (scaffolds) for bone tissue engineering. Such parameters as temperature, monomer/enzyme ratio, and monomer concentration were studied. The maximum molecular weight of synthesized polymers was about 90,000. Methods allowing the introduction of reactive double bonds into polypentadecalactone (polyPDL) structure were developed. The macroporous matrices were obtained by modification of thermoinduced phase separation method.http://dx.doi.org/10.1155/2013/476748
collection DOAJ
language English
format Article
sources DOAJ
author V. A. Korzhikov
K. V. Gusevskaya
E. N. Litvinchuk
E. G. Vlakh
T. B. Tennikova
spellingShingle V. A. Korzhikov
K. V. Gusevskaya
E. N. Litvinchuk
E. G. Vlakh
T. B. Tennikova
Enzyme-Mediated Ring-Opening Polymerization of Pentadecalactone to Obtain Biodegradable Polymer for Fabrication of Scaffolds for Bone Tissue Engineering
International Journal of Polymer Science
author_facet V. A. Korzhikov
K. V. Gusevskaya
E. N. Litvinchuk
E. G. Vlakh
T. B. Tennikova
author_sort V. A. Korzhikov
title Enzyme-Mediated Ring-Opening Polymerization of Pentadecalactone to Obtain Biodegradable Polymer for Fabrication of Scaffolds for Bone Tissue Engineering
title_short Enzyme-Mediated Ring-Opening Polymerization of Pentadecalactone to Obtain Biodegradable Polymer for Fabrication of Scaffolds for Bone Tissue Engineering
title_full Enzyme-Mediated Ring-Opening Polymerization of Pentadecalactone to Obtain Biodegradable Polymer for Fabrication of Scaffolds for Bone Tissue Engineering
title_fullStr Enzyme-Mediated Ring-Opening Polymerization of Pentadecalactone to Obtain Biodegradable Polymer for Fabrication of Scaffolds for Bone Tissue Engineering
title_full_unstemmed Enzyme-Mediated Ring-Opening Polymerization of Pentadecalactone to Obtain Biodegradable Polymer for Fabrication of Scaffolds for Bone Tissue Engineering
title_sort enzyme-mediated ring-opening polymerization of pentadecalactone to obtain biodegradable polymer for fabrication of scaffolds for bone tissue engineering
publisher Hindawi Limited
series International Journal of Polymer Science
issn 1687-9422
1687-9430
publishDate 2013-01-01
description The optimization of enzyme-mediated polymerization of pentadecalactone (PDL) was performed to obtain macromolecular products suitable for generation of 3D cell supports (scaffolds) for bone tissue engineering. Such parameters as temperature, monomer/enzyme ratio, and monomer concentration were studied. The maximum molecular weight of synthesized polymers was about 90,000. Methods allowing the introduction of reactive double bonds into polypentadecalactone (polyPDL) structure were developed. The macroporous matrices were obtained by modification of thermoinduced phase separation method.
url http://dx.doi.org/10.1155/2013/476748
work_keys_str_mv AT vakorzhikov enzymemediatedringopeningpolymerizationofpentadecalactonetoobtainbiodegradablepolymerforfabricationofscaffoldsforbonetissueengineering
AT kvgusevskaya enzymemediatedringopeningpolymerizationofpentadecalactonetoobtainbiodegradablepolymerforfabricationofscaffoldsforbonetissueengineering
AT enlitvinchuk enzymemediatedringopeningpolymerizationofpentadecalactonetoobtainbiodegradablepolymerforfabricationofscaffoldsforbonetissueengineering
AT egvlakh enzymemediatedringopeningpolymerizationofpentadecalactonetoobtainbiodegradablepolymerforfabricationofscaffoldsforbonetissueengineering
AT tbtennikova enzymemediatedringopeningpolymerizationofpentadecalactonetoobtainbiodegradablepolymerforfabricationofscaffoldsforbonetissueengineering
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