Gap19, a Cx43 Hemichannel Inhibitor, Acts as a Gating Modifier That Decreases Main State Opening While Increasing Substate Gating

Gap19, a Cx43 Hemichannel Inhibitor, Acts as a Gating Modifier That Decreases Main State Opening While Increasing Substate Gating

Cx43 hemichannels (HCs) are electrically and chemically gated transmembrane pores with low open probability and multiple conductance states, which makes kinetic studies of channel gating in large datasets challenging. Here, we developed open access software, named HemiGUI, to analyze HC gating trans...

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Bibliographic Details
Main Authors: Alessio Lissoni, Nan Wang, Timur Nezlobinskii, Maarten De Smet, Alexander V. Panfilov, Nele Vandersickel, Luc Leybaert, Katja Witschas
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
channel gating
graphic user interface
automated analysis
transition analysis
Online Access:https://www.mdpi.com/1422-0067/21/19/7340

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