Kindlin-2 links mechano-environment to proline synthesis and tumor growth

The mechano-properties of the Extracellular Matrix (ECM) are important for tumorigenesis. Here, the authors show that the stiffening of the ECM promotes translocation of the focal adhesion protein—Kindlin-2—to the mitochondria, where it interacts with the proline synthesis enzyme PYCR1, stimulating...

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Main Authors:	Ling Guo, Chunhong Cui, Kuo Zhang, Jiaxin Wang, Yilin Wang, Yixuan Lu, Ka Chen, Jifan Yuan, Guozhi Xiao, Bin Tang, Ying Sun, Chuanyue Wu
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-08772-3

id	doaj-41baf5a45eef4a66bff8a2e90d14d799
record_format	Article
spelling	doaj-41baf5a45eef4a66bff8a2e90d14d7992021-05-11T12:21:55ZengNature Publishing GroupNature Communications2041-17232019-02-0110112010.1038/s41467-019-08772-3Kindlin-2 links mechano-environment to proline synthesis and tumor growthLing Guo0Chunhong Cui1Kuo Zhang2Jiaxin Wang3Yilin Wang4Yixuan Lu5Ka Chen6Jifan Yuan7Guozhi Xiao8Bin Tang9Ying Sun10Chuanyue Wu11Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Department of Biology and Academy for Advanced Interdisciplinary Studies, Southern University of Science and TechnologyGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Department of Biology and Academy for Advanced Interdisciplinary Studies, Southern University of Science and TechnologyGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Department of Biology and Academy for Advanced Interdisciplinary Studies, Southern University of Science and TechnologyGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Department of Biology and Academy for Advanced Interdisciplinary Studies, Southern University of Science and TechnologyGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Department of Biology and Academy for Advanced Interdisciplinary Studies, Southern University of Science and TechnologyGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Department of Biology and Academy for Advanced Interdisciplinary Studies, Southern University of Science and TechnologyDepartment of Pathology, University of Pittsburgh School of MedicineGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Department of Biology and Academy for Advanced Interdisciplinary Studies, Southern University of Science and TechnologyGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Department of Biology and Academy for Advanced Interdisciplinary Studies, Southern University of Science and TechnologyGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Department of Biology and Academy for Advanced Interdisciplinary Studies, Southern University of Science and TechnologyGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Department of Biology and Academy for Advanced Interdisciplinary Studies, Southern University of Science and TechnologyDepartment of Pathology, University of Pittsburgh School of MedicineThe mechano-properties of the Extracellular Matrix (ECM) are important for tumorigenesis. Here, the authors show that the stiffening of the ECM promotes translocation of the focal adhesion protein—Kindlin-2—to the mitochondria, where it interacts with the proline synthesis enzyme PYCR1, stimulating proline synthesis and cell proliferation.https://doi.org/10.1038/s41467-019-08772-3
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ling Guo Chunhong Cui Kuo Zhang Jiaxin Wang Yilin Wang Yixuan Lu Ka Chen Jifan Yuan Guozhi Xiao Bin Tang Ying Sun Chuanyue Wu
spellingShingle	Ling Guo Chunhong Cui Kuo Zhang Jiaxin Wang Yilin Wang Yixuan Lu Ka Chen Jifan Yuan Guozhi Xiao Bin Tang Ying Sun Chuanyue Wu Kindlin-2 links mechano-environment to proline synthesis and tumor growth Nature Communications
author_facet	Ling Guo Chunhong Cui Kuo Zhang Jiaxin Wang Yilin Wang Yixuan Lu Ka Chen Jifan Yuan Guozhi Xiao Bin Tang Ying Sun Chuanyue Wu
author_sort	Ling Guo
title	Kindlin-2 links mechano-environment to proline synthesis and tumor growth
title_short	Kindlin-2 links mechano-environment to proline synthesis and tumor growth
title_full	Kindlin-2 links mechano-environment to proline synthesis and tumor growth
title_fullStr	Kindlin-2 links mechano-environment to proline synthesis and tumor growth
title_full_unstemmed	Kindlin-2 links mechano-environment to proline synthesis and tumor growth
title_sort	kindlin-2 links mechano-environment to proline synthesis and tumor growth
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-02-01
description	The mechano-properties of the Extracellular Matrix (ECM) are important for tumorigenesis. Here, the authors show that the stiffening of the ECM promotes translocation of the focal adhesion protein—Kindlin-2—to the mitochondria, where it interacts with the proline synthesis enzyme PYCR1, stimulating proline synthesis and cell proliferation.
url	https://doi.org/10.1038/s41467-019-08772-3
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Kindlin-2 links mechano-environment to proline synthesis and tumor growth

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