Kindlin-2 links mechano-environment to proline synthesis and tumor growth
The mechano-properties of the Extracellular Matrix (ECM) are important for tumorigenesis. Here, the authors show that the stiffening of the ECM promotes translocation of the focal adhesion protein—Kindlin-2—to the mitochondria, where it interacts with the proline synthesis enzyme PYCR1, stimulating...
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Bibliographic Details
| Main Authors: |
Ling Guo,
Chunhong Cui,
Kuo Zhang,
Jiaxin Wang,
Yilin Wang,
Yixuan Lu,
Ka Chen,
Jifan Yuan,
Guozhi Xiao,
Bin Tang,
Ying Sun,
Chuanyue Wu |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2019-02-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-019-08772-3
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