A Concise Synthesis of Three Branches Derived from Polysaccharide RN1 and Anti-Pancreatic Cancer Activity Study

A Concise Synthesis of Three Branches Derived from Polysaccharide RN1 and Anti-Pancreatic Cancer Activity Study

RN1, a polysaccharide from flowers of Panax pseudo-ginsieng Wall. Var. notoginseng (Burkill) Hoo & Tseng, is a potential multi-targeting drug candidate for pancreatic cancer treatment. However, the active targeting domain of RN1 is still unknown. Herein, three RN1 derived branches were synth...

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Main Authors: Deqin Cai, Yanli Yao, Yubo Tang, Zheng Wang, Wei Shi, Wei Huang, Kan Ding
Format: Article
Language:English
Published: MDPI AG 2017-10-01
Series:Polymers
Subjects:
arabinogalactan
pancreatic cancer
gemcitabine resistance
carbohydrate chemistry
Online Access:https://www.mdpi.com/2073-4360/9/10/536
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spelling doaj-41b707aeddf44f38b70146fcda713c6c2020-11-25T01:49:57ZengMDPI AGPolymers2073-43602017-10-0191053610.3390/polym9100536polym9100536A Concise Synthesis of Three Branches Derived from Polysaccharide RN1 and Anti-Pancreatic Cancer Activity StudyDeqin Cai0Yanli Yao1Yubo Tang2Zheng Wang3Wei Shi4Wei Huang5Kan Ding6University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, ChinaUniversity of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, ChinaCAS Key Laboratory of Receptor Research, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Pudong, Shanghai 201203, ChinaGlycochemistry and Glycobiology Lab, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, ChinaUniversity of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, ChinaUniversity of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, ChinaUniversity of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, ChinaRN1, a polysaccharide from flowers of Panax pseudo-ginsieng Wall. Var. notoginseng (Burkill) Hoo & Tseng, is a potential multi-targeting drug candidate for pancreatic cancer treatment. However, the active targeting domain of RN1 is still unknown. Herein, three RN1 derived branches were synthesized via [3+2] or [2+2] strategies, efficiently. Two pentasaccharides, 18 and 27, showed similar inhibition effect on pancreatic cancer BxPC-3 cells to that of RN1 at same concentration. Interestingly, tetrasaccharide 21 potently inhibited gemcitabineresistant cell line Panc-1 at high concentration. These suggest that the branches of RN1 might be the active targeting domain and tetrasaccharide 21 might be a potential leading compound for pancreatic cancer with gemcitabine resistance.https://www.mdpi.com/2073-4360/9/10/536arabinogalactanpancreatic cancergemcitabine resistancecarbohydrate chemistry
collection DOAJ
language English
format Article
sources DOAJ
author Deqin Cai
Yanli Yao
Yubo Tang
Zheng Wang
Wei Shi
Wei Huang
Kan Ding
spellingShingle Deqin Cai
Yanli Yao
Yubo Tang
Zheng Wang
Wei Shi
Wei Huang
Kan Ding
A Concise Synthesis of Three Branches Derived from Polysaccharide RN1 and Anti-Pancreatic Cancer Activity Study
Polymers
arabinogalactan
pancreatic cancer
gemcitabine resistance
carbohydrate chemistry
author_facet Deqin Cai
Yanli Yao
Yubo Tang
Zheng Wang
Wei Shi
Wei Huang
Kan Ding
author_sort Deqin Cai
title A Concise Synthesis of Three Branches Derived from Polysaccharide RN1 and Anti-Pancreatic Cancer Activity Study
title_short A Concise Synthesis of Three Branches Derived from Polysaccharide RN1 and Anti-Pancreatic Cancer Activity Study
title_full A Concise Synthesis of Three Branches Derived from Polysaccharide RN1 and Anti-Pancreatic Cancer Activity Study
title_fullStr A Concise Synthesis of Three Branches Derived from Polysaccharide RN1 and Anti-Pancreatic Cancer Activity Study
title_full_unstemmed A Concise Synthesis of Three Branches Derived from Polysaccharide RN1 and Anti-Pancreatic Cancer Activity Study
title_sort concise synthesis of three branches derived from polysaccharide rn1 and anti-pancreatic cancer activity study
publisher MDPI AG
series Polymers
issn 2073-4360
publishDate 2017-10-01
description RN1, a polysaccharide from flowers of Panax pseudo-ginsieng Wall. Var. notoginseng (Burkill) Hoo & Tseng, is a potential multi-targeting drug candidate for pancreatic cancer treatment. However, the active targeting domain of RN1 is still unknown. Herein, three RN1 derived branches were synthesized via [3+2] or [2+2] strategies, efficiently. Two pentasaccharides, 18 and 27, showed similar inhibition effect on pancreatic cancer BxPC-3 cells to that of RN1 at same concentration. Interestingly, tetrasaccharide 21 potently inhibited gemcitabineresistant cell line Panc-1 at high concentration. These suggest that the branches of RN1 might be the active targeting domain and tetrasaccharide 21 might be a potential leading compound for pancreatic cancer with gemcitabine resistance.
topic arabinogalactan
pancreatic cancer
gemcitabine resistance
carbohydrate chemistry
url https://www.mdpi.com/2073-4360/9/10/536
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