Novel leukocyte-depleted platelet-rich plasma-based skin equivalent as an in vitro model of chronic wounds: a preliminary study

Novel leukocyte-depleted platelet-rich plasma-based skin equivalent as an in vitro model of chronic wounds: a preliminary study

Abstract Background Chronic leg ulcerations are associated with Haemoglobin disorders, Type2 Diabetes Mellitus, and long-term venous insufficiency, where poor perfusion and altered metabolism develop into a chronic inflammation that impairs wound closure. Skin equivalent organotypic cultures can be...

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Bibliographic Details
Main Authors: Elisa Seria, George Galea, Joseph Borg, Kevin Schembri, Gabriella Grech, Sarah Samut Tagliaferro, Alexander Felice
Format: Article
Language:English
Published: BMC 2021-05-01
Series:BMC Molecular and Cell Biology
Subjects:
Wound healing
Biomaterials
Platelet rich plasma
Skin equivalent
Inflammation
Online Access:https://doi.org/10.1186/s12860-021-00366-6

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