Inflammasomes as therapeutic targets in human diseases

Abstract Inflammasomes are protein complexes of the innate immune system that initiate inflammation in response to either exogenous pathogens or endogenous danger signals. Inflammasome multiprotein complexes are composed of three parts: a sensor protein, an adaptor, and pro-caspase-1. Activation of...

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Bibliographic Details
Main Authors: Yangxin Li, Hui Huang, Bin Liu, Yu Zhang, Xiangbin Pan, Xi-Yong Yu, Zhenya Shen, Yao-Hua Song
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-021-00650-z