Cardiovascular System Under Simulated Weightlessness: Head-Down Bed Rest vs. Dry Immersion

BackgroundThe most applicable human models of weightlessness are −6° head-down bed rest (HDBR) and head-out dry immersion (DI). A detailed experimental comparison of cardiovascular responses in both models has not yet been carried out, in spite of numerous studies having been performed in each of th...

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Main Authors: Liubov Amirova, Nastassia Navasiolava, Ilya Rukavishvikov, Guillemette Gauquelin-Koch, Claude Gharib, Inessa Kozlovskaya, Marc-Antoine Custaud, Elena Tomilovskaya
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Physiology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00395/full
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spelling doaj-41b07b94b903497cb755b7e1c87ad97c2020-11-25T03:53:20ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-05-011110.3389/fphys.2020.00395508017Cardiovascular System Under Simulated Weightlessness: Head-Down Bed Rest vs. Dry ImmersionLiubov Amirova0Liubov Amirova1Nastassia Navasiolava2Ilya Rukavishvikov3Guillemette Gauquelin-Koch4Claude Gharib5Inessa Kozlovskaya6Marc-Antoine Custaud7Marc-Antoine Custaud8Elena Tomilovskaya9Laboratory of Gravitational Physiology of the Sensorimotor System, Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, RussiaLaboratoire MITOVASC, UMR Institut National de la Santé et de la Recherche Médicale 1083, Centre National de la Recherche Scientifique 6015, Université d’Angers, Angers, FranceLaboratoire MITOVASC, UMR Institut National de la Santé et de la Recherche Médicale 1083, Centre National de la Recherche Scientifique 6015, Université d’Angers, Angers, FranceLaboratory of Gravitational Physiology of the Sensorimotor System, Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, RussiaCentre National d’Etudes Spatiales, Paris, FranceInstitut NeuroMyogène, Université Claude Bernard Lyon 1, Lyon, FranceLaboratory of Gravitational Physiology of the Sensorimotor System, Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, RussiaLaboratoire MITOVASC, UMR Institut National de la Santé et de la Recherche Médicale 1083, Centre National de la Recherche Scientifique 6015, Université d’Angers, Angers, FranceCentre de Recherche Clinique, Centre Hospitalier Universitaire d’Angers, Angers, FranceLaboratory of Gravitational Physiology of the Sensorimotor System, Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, RussiaBackgroundThe most applicable human models of weightlessness are −6° head-down bed rest (HDBR) and head-out dry immersion (DI). A detailed experimental comparison of cardiovascular responses in both models has not yet been carried out, in spite of numerous studies having been performed in each of the models separately.ObjectivesWe compared changes in central hemodynamics, autonomic regulation, plasma volume, and water balance induced by −6° HDBR and DI.MethodsEleven subjects participated in a 21-day HDBR and 12 subjects in a 3-day DI. During exposure, measurements of the water balance, blood pressure, and heart rate were performed daily. Plasma volume evolution was assessed by the Dill–Costill method. In order to assess orthostatic tolerance time (OTT), central hemodynamic responses to orthostatic stimuli, and autonomous regulation, the 80° lower body negative pressure–tilt test was conducted before and right after both exposures.ResultsFor most of the studied parameters, the changes were co-directional, although they differed in their extent. The changes in systolic blood pressure and total peripheral resistance after HDBR were more pronounced than those after DI. The OTT was decreased in both groups: to 14.2 ± 3.1 min (vs. 27.9 ± 2.5 min before exposure) in the group of 21-day HDBR and to 8.7 ± 2.1 min (vs. 27.7 ± 1.2 min before exposure) in the group of 3-day DI.ConclusionsIn general, cardiovascular changes during the 21-day HDBR and 3-day DI were co-directional. In some cases, changes in the parameters after 3-day DI exceeded changes after the 21-day HDBR, while in other cases the opposite was true. Significantly stronger effects of DI on cardiovascular function may be due to hypovolemia and support unloading (supportlessness).https://www.frontiersin.org/article/10.3389/fphys.2020.00395/fullsupport unloadinglower body negative pressurewater balanceorthostatic toleranceautonomous regulationmicrogravity models
collection DOAJ
language English
format Article
sources DOAJ
author Liubov Amirova
Liubov Amirova
Nastassia Navasiolava
Ilya Rukavishvikov
Guillemette Gauquelin-Koch
Claude Gharib
Inessa Kozlovskaya
Marc-Antoine Custaud
Marc-Antoine Custaud
Elena Tomilovskaya
spellingShingle Liubov Amirova
Liubov Amirova
Nastassia Navasiolava
Ilya Rukavishvikov
Guillemette Gauquelin-Koch
Claude Gharib
Inessa Kozlovskaya
Marc-Antoine Custaud
Marc-Antoine Custaud
Elena Tomilovskaya
Cardiovascular System Under Simulated Weightlessness: Head-Down Bed Rest vs. Dry Immersion
Frontiers in Physiology
support unloading
lower body negative pressure
water balance
orthostatic tolerance
autonomous regulation
microgravity models
author_facet Liubov Amirova
Liubov Amirova
Nastassia Navasiolava
Ilya Rukavishvikov
Guillemette Gauquelin-Koch
Claude Gharib
Inessa Kozlovskaya
Marc-Antoine Custaud
Marc-Antoine Custaud
Elena Tomilovskaya
author_sort Liubov Amirova
title Cardiovascular System Under Simulated Weightlessness: Head-Down Bed Rest vs. Dry Immersion
title_short Cardiovascular System Under Simulated Weightlessness: Head-Down Bed Rest vs. Dry Immersion
title_full Cardiovascular System Under Simulated Weightlessness: Head-Down Bed Rest vs. Dry Immersion
title_fullStr Cardiovascular System Under Simulated Weightlessness: Head-Down Bed Rest vs. Dry Immersion
title_full_unstemmed Cardiovascular System Under Simulated Weightlessness: Head-Down Bed Rest vs. Dry Immersion
title_sort cardiovascular system under simulated weightlessness: head-down bed rest vs. dry immersion
publisher Frontiers Media S.A.
series Frontiers in Physiology
issn 1664-042X
publishDate 2020-05-01
description BackgroundThe most applicable human models of weightlessness are −6° head-down bed rest (HDBR) and head-out dry immersion (DI). A detailed experimental comparison of cardiovascular responses in both models has not yet been carried out, in spite of numerous studies having been performed in each of the models separately.ObjectivesWe compared changes in central hemodynamics, autonomic regulation, plasma volume, and water balance induced by −6° HDBR and DI.MethodsEleven subjects participated in a 21-day HDBR and 12 subjects in a 3-day DI. During exposure, measurements of the water balance, blood pressure, and heart rate were performed daily. Plasma volume evolution was assessed by the Dill–Costill method. In order to assess orthostatic tolerance time (OTT), central hemodynamic responses to orthostatic stimuli, and autonomous regulation, the 80° lower body negative pressure–tilt test was conducted before and right after both exposures.ResultsFor most of the studied parameters, the changes were co-directional, although they differed in their extent. The changes in systolic blood pressure and total peripheral resistance after HDBR were more pronounced than those after DI. The OTT was decreased in both groups: to 14.2 ± 3.1 min (vs. 27.9 ± 2.5 min before exposure) in the group of 21-day HDBR and to 8.7 ± 2.1 min (vs. 27.7 ± 1.2 min before exposure) in the group of 3-day DI.ConclusionsIn general, cardiovascular changes during the 21-day HDBR and 3-day DI were co-directional. In some cases, changes in the parameters after 3-day DI exceeded changes after the 21-day HDBR, while in other cases the opposite was true. Significantly stronger effects of DI on cardiovascular function may be due to hypovolemia and support unloading (supportlessness).
topic support unloading
lower body negative pressure
water balance
orthostatic tolerance
autonomous regulation
microgravity models
url https://www.frontiersin.org/article/10.3389/fphys.2020.00395/full
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