Cardiovascular System Under Simulated Weightlessness: Head-Down Bed Rest vs. Dry Immersion
BackgroundThe most applicable human models of weightlessness are −6° head-down bed rest (HDBR) and head-out dry immersion (DI). A detailed experimental comparison of cardiovascular responses in both models has not yet been carried out, in spite of numerous studies having been performed in each of th...
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doaj-41b07b94b903497cb755b7e1c87ad97c2020-11-25T03:53:20ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-05-011110.3389/fphys.2020.00395508017Cardiovascular System Under Simulated Weightlessness: Head-Down Bed Rest vs. Dry ImmersionLiubov Amirova0Liubov Amirova1Nastassia Navasiolava2Ilya Rukavishvikov3Guillemette Gauquelin-Koch4Claude Gharib5Inessa Kozlovskaya6Marc-Antoine Custaud7Marc-Antoine Custaud8Elena Tomilovskaya9Laboratory of Gravitational Physiology of the Sensorimotor System, Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, RussiaLaboratoire MITOVASC, UMR Institut National de la Santé et de la Recherche Médicale 1083, Centre National de la Recherche Scientifique 6015, Université d’Angers, Angers, FranceLaboratoire MITOVASC, UMR Institut National de la Santé et de la Recherche Médicale 1083, Centre National de la Recherche Scientifique 6015, Université d’Angers, Angers, FranceLaboratory of Gravitational Physiology of the Sensorimotor System, Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, RussiaCentre National d’Etudes Spatiales, Paris, FranceInstitut NeuroMyogène, Université Claude Bernard Lyon 1, Lyon, FranceLaboratory of Gravitational Physiology of the Sensorimotor System, Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, RussiaLaboratoire MITOVASC, UMR Institut National de la Santé et de la Recherche Médicale 1083, Centre National de la Recherche Scientifique 6015, Université d’Angers, Angers, FranceCentre de Recherche Clinique, Centre Hospitalier Universitaire d’Angers, Angers, FranceLaboratory of Gravitational Physiology of the Sensorimotor System, Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, RussiaBackgroundThe most applicable human models of weightlessness are −6° head-down bed rest (HDBR) and head-out dry immersion (DI). A detailed experimental comparison of cardiovascular responses in both models has not yet been carried out, in spite of numerous studies having been performed in each of the models separately.ObjectivesWe compared changes in central hemodynamics, autonomic regulation, plasma volume, and water balance induced by −6° HDBR and DI.MethodsEleven subjects participated in a 21-day HDBR and 12 subjects in a 3-day DI. During exposure, measurements of the water balance, blood pressure, and heart rate were performed daily. Plasma volume evolution was assessed by the Dill–Costill method. In order to assess orthostatic tolerance time (OTT), central hemodynamic responses to orthostatic stimuli, and autonomous regulation, the 80° lower body negative pressure–tilt test was conducted before and right after both exposures.ResultsFor most of the studied parameters, the changes were co-directional, although they differed in their extent. The changes in systolic blood pressure and total peripheral resistance after HDBR were more pronounced than those after DI. The OTT was decreased in both groups: to 14.2 ± 3.1 min (vs. 27.9 ± 2.5 min before exposure) in the group of 21-day HDBR and to 8.7 ± 2.1 min (vs. 27.7 ± 1.2 min before exposure) in the group of 3-day DI.ConclusionsIn general, cardiovascular changes during the 21-day HDBR and 3-day DI were co-directional. In some cases, changes in the parameters after 3-day DI exceeded changes after the 21-day HDBR, while in other cases the opposite was true. Significantly stronger effects of DI on cardiovascular function may be due to hypovolemia and support unloading (supportlessness).https://www.frontiersin.org/article/10.3389/fphys.2020.00395/fullsupport unloadinglower body negative pressurewater balanceorthostatic toleranceautonomous regulationmicrogravity models |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Liubov Amirova Liubov Amirova Nastassia Navasiolava Ilya Rukavishvikov Guillemette Gauquelin-Koch Claude Gharib Inessa Kozlovskaya Marc-Antoine Custaud Marc-Antoine Custaud Elena Tomilovskaya |
spellingShingle |
Liubov Amirova Liubov Amirova Nastassia Navasiolava Ilya Rukavishvikov Guillemette Gauquelin-Koch Claude Gharib Inessa Kozlovskaya Marc-Antoine Custaud Marc-Antoine Custaud Elena Tomilovskaya Cardiovascular System Under Simulated Weightlessness: Head-Down Bed Rest vs. Dry Immersion Frontiers in Physiology support unloading lower body negative pressure water balance orthostatic tolerance autonomous regulation microgravity models |
author_facet |
Liubov Amirova Liubov Amirova Nastassia Navasiolava Ilya Rukavishvikov Guillemette Gauquelin-Koch Claude Gharib Inessa Kozlovskaya Marc-Antoine Custaud Marc-Antoine Custaud Elena Tomilovskaya |
author_sort |
Liubov Amirova |
title |
Cardiovascular System Under Simulated Weightlessness: Head-Down Bed Rest vs. Dry Immersion |
title_short |
Cardiovascular System Under Simulated Weightlessness: Head-Down Bed Rest vs. Dry Immersion |
title_full |
Cardiovascular System Under Simulated Weightlessness: Head-Down Bed Rest vs. Dry Immersion |
title_fullStr |
Cardiovascular System Under Simulated Weightlessness: Head-Down Bed Rest vs. Dry Immersion |
title_full_unstemmed |
Cardiovascular System Under Simulated Weightlessness: Head-Down Bed Rest vs. Dry Immersion |
title_sort |
cardiovascular system under simulated weightlessness: head-down bed rest vs. dry immersion |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2020-05-01 |
description |
BackgroundThe most applicable human models of weightlessness are −6° head-down bed rest (HDBR) and head-out dry immersion (DI). A detailed experimental comparison of cardiovascular responses in both models has not yet been carried out, in spite of numerous studies having been performed in each of the models separately.ObjectivesWe compared changes in central hemodynamics, autonomic regulation, plasma volume, and water balance induced by −6° HDBR and DI.MethodsEleven subjects participated in a 21-day HDBR and 12 subjects in a 3-day DI. During exposure, measurements of the water balance, blood pressure, and heart rate were performed daily. Plasma volume evolution was assessed by the Dill–Costill method. In order to assess orthostatic tolerance time (OTT), central hemodynamic responses to orthostatic stimuli, and autonomous regulation, the 80° lower body negative pressure–tilt test was conducted before and right after both exposures.ResultsFor most of the studied parameters, the changes were co-directional, although they differed in their extent. The changes in systolic blood pressure and total peripheral resistance after HDBR were more pronounced than those after DI. The OTT was decreased in both groups: to 14.2 ± 3.1 min (vs. 27.9 ± 2.5 min before exposure) in the group of 21-day HDBR and to 8.7 ± 2.1 min (vs. 27.7 ± 1.2 min before exposure) in the group of 3-day DI.ConclusionsIn general, cardiovascular changes during the 21-day HDBR and 3-day DI were co-directional. In some cases, changes in the parameters after 3-day DI exceeded changes after the 21-day HDBR, while in other cases the opposite was true. Significantly stronger effects of DI on cardiovascular function may be due to hypovolemia and support unloading (supportlessness). |
topic |
support unloading lower body negative pressure water balance orthostatic tolerance autonomous regulation microgravity models |
url |
https://www.frontiersin.org/article/10.3389/fphys.2020.00395/full |
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