Stability of Methylphenidate under Various pH Conditions in the Presence or Absence of Gut Microbiota

Stability of Methylphenidate under Various pH Conditions in the Presence or Absence of Gut Microbiota

Methylphenidate is one of the most widely used oral treatments for attention-deficit/hyperactivity disorder (ADHD). The drug is mainly absorbed in the small intestine and has low bioavailability. Accordingly, a high interindividual variability in terms of response to the treatment is known among ADH...

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Bibliographic Details
Main Authors: Julia Aresti-Sanz, Markus Schwalbe, Rob Rodrigues Pereira, Hjalmar Permentier, Sahar El Aidy
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Pharmaceuticals
Subjects:
Retalin
metabolism
availability
intestinal pH
gut bacteria
Online Access:https://www.mdpi.com/1424-8247/14/8/733

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