Porphyromonas gingivalis bypasses epithelial barrier and modulates fibroblastic inflammatory response in an in vitro 3D spheroid model

Porphyromonas gingivalis bypasses epithelial barrier and modulates fibroblastic inflammatory response in an in vitro 3D spheroid model

Abstract Porphyromonas gingivalis-induced inflammatory effects are mostly investigated in monolayer cultured cells. The aim of this study was to develop a 3D spheroid model of gingiva to take into account epithelio-fibroblastic interactions. Human gingival epithelial cells (ECs) and human oral fibro...

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Bibliographic Details
Main Authors: Isaac Maximiliano Bugueno, Fareeha Batool, Laetitia Keller, Sabine Kuchler-Bopp, Nadia Benkirane-Jessel, Olivier Huck
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Scientific Reports
Subjects:
Epithelial Barrier
Experimental Periodontitis
Human Oral Fibroblasts
Epithelium-connective Tissue Interface
Gingivalis Infection
Online Access:https://doi.org/10.1038/s41598-018-33267-4

Internet

https://doi.org/10.1038/s41598-018-33267-4

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