Rescue Therapy for Genotype-3 DAA Non-responders, Almost all Done

Rescue Therapy for Genotype-3 DAA Non-responders, Almost all Done

Nowadays, the retreatment of patients with Hepatitis C virus (HCV) genotype 3 (GT3) especially cirrhotic, who have already been treated with regimens containing a NS5A inhibitor represents a challenge. Use a novel retreatment option for patients with a difficult approach. We present three case repor...

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Main Authors: Susana Llerena, Joaquín Cabezas, Antonio Cuadrado, José Manuel Olmos, Marta González, Federico García, Carmen Cobo, Javier Crespo
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Annals of Hepatology
Subjects:
Hepatitis C virus
Treatment failure
Genotype 3
Sofosbuvir
Grazoprevir + Elbasvir
Online Access:http://www.sciencedirect.com/science/article/pii/S1665268119303291
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spelling doaj-41a11c876d5b4bab86e156bb92820e022021-06-09T05:50:56ZengElsevierAnnals of Hepatology1665-26812019-01-01181236239Rescue Therapy for Genotype-3 DAA Non-responders, Almost all DoneSusana Llerena0Joaquín Cabezas1Antonio Cuadrado2José Manuel Olmos3Marta González4Federico García5Carmen Cobo6Javier Crespo7Gastroenterology and Hepatology Department, Hospital Universitario Marques de Valdecilla, Santander, Spain; Infection, Immunity and Digestive Disease Group, Instituto de Investigation Valdecilla (IDIVAL), Santander, SpainGastroenterology and Hepatology Department, Hospital Universitario Marques de Valdecilla, Santander, Spain; Infection, Immunity and Digestive Disease Group, Instituto de Investigation Valdecilla (IDIVAL), Santander, SpainGastroenterology and Hepatology Department, Hospital Universitario Marques de Valdecilla, Santander, Spain; Infection, Immunity and Digestive Disease Group, Instituto de Investigation Valdecilla (IDIVAL), Santander, SpainGastroenterology and Hepatology Department, Hospital Universitario Marques de Valdecilla, Santander, Spain; Infection, Immunity and Digestive Disease Group, Instituto de Investigation Valdecilla (IDIVAL), Santander, SpainGastroenterology and Hepatology Department, Hospital Universitario Marques de Valdecilla, Santander, Spain; Infection, Immunity and Digestive Disease Group, Instituto de Investigation Valdecilla (IDIVAL), Santander, SpainClinical Microbiology Department; Infectious Diseases and Clinical Microbiology Unit. Hospital Universitario San Cecilio, Granada. SpainMedical Service, Centro Penitenciario El Dueso, Santona, SpainGastroenterology and Hepatology Department, Hospital Universitario Marques de Valdecilla, Santander, Spain; Infection, Immunity and Digestive Disease Group, Instituto de Investigation Valdecilla (IDIVAL), Santander, Spain; Correspondence and reprint request:Nowadays, the retreatment of patients with Hepatitis C virus (HCV) genotype 3 (GT3) especially cirrhotic, who have already been treated with regimens containing a NS5A inhibitor represents a challenge. Use a novel retreatment option for patients with a difficult approach. We present three case reports of retreatment with a new combination of Direct-acting antivirals (DAAs), Sofosbuvir, Elbasvir/Grazoprevir in patients with GT3 with a previous failure with Sofosbuvir/Ledipasvir. All the cases achieved sustained virologic response (SVR) at week +12 without adverse effects. In our experience, this combo may represent an effective and safe option for these patients.http://www.sciencedirect.com/science/article/pii/S1665268119303291Hepatitis C virusTreatment failureGenotype 3SofosbuvirGrazoprevir + Elbasvir
collection DOAJ
language English
format Article
sources DOAJ
author Susana Llerena
Joaquín Cabezas
Antonio Cuadrado
José Manuel Olmos
Marta González
Federico García
Carmen Cobo
Javier Crespo
spellingShingle Susana Llerena
Joaquín Cabezas
Antonio Cuadrado
José Manuel Olmos
Marta González
Federico García
Carmen Cobo
Javier Crespo
Rescue Therapy for Genotype-3 DAA Non-responders, Almost all Done
Annals of Hepatology
Hepatitis C virus
Treatment failure
Genotype 3
Sofosbuvir
Grazoprevir + Elbasvir
author_facet Susana Llerena
Joaquín Cabezas
Antonio Cuadrado
José Manuel Olmos
Marta González
Federico García
Carmen Cobo
Javier Crespo
author_sort Susana Llerena
title Rescue Therapy for Genotype-3 DAA Non-responders, Almost all Done
title_short Rescue Therapy for Genotype-3 DAA Non-responders, Almost all Done
title_full Rescue Therapy for Genotype-3 DAA Non-responders, Almost all Done
title_fullStr Rescue Therapy for Genotype-3 DAA Non-responders, Almost all Done
title_full_unstemmed Rescue Therapy for Genotype-3 DAA Non-responders, Almost all Done
title_sort rescue therapy for genotype-3 daa non-responders, almost all done
publisher Elsevier
series Annals of Hepatology
issn 1665-2681
publishDate 2019-01-01
description Nowadays, the retreatment of patients with Hepatitis C virus (HCV) genotype 3 (GT3) especially cirrhotic, who have already been treated with regimens containing a NS5A inhibitor represents a challenge. Use a novel retreatment option for patients with a difficult approach. We present three case reports of retreatment with a new combination of Direct-acting antivirals (DAAs), Sofosbuvir, Elbasvir/Grazoprevir in patients with GT3 with a previous failure with Sofosbuvir/Ledipasvir. All the cases achieved sustained virologic response (SVR) at week +12 without adverse effects. In our experience, this combo may represent an effective and safe option for these patients.
topic Hepatitis C virus
Treatment failure
Genotype 3
Sofosbuvir
Grazoprevir + Elbasvir
url http://www.sciencedirect.com/science/article/pii/S1665268119303291
work_keys_str_mv AT susanallerena rescuetherapyforgenotype3daanonrespondersalmostalldone
AT joaquincabezas rescuetherapyforgenotype3daanonrespondersalmostalldone
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AT josemanuelolmos rescuetherapyforgenotype3daanonrespondersalmostalldone
AT martagonzalez rescuetherapyforgenotype3daanonrespondersalmostalldone
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AT carmencobo rescuetherapyforgenotype3daanonrespondersalmostalldone
AT javiercrespo rescuetherapyforgenotype3daanonrespondersalmostalldone
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