Antioxidant activity and antibacterial evaluation of new thiazolin-4-one derivatives as potential tryptophanyl-tRNA synthetase inhibitors

Antioxidant activity and antibacterial evaluation of new thiazolin-4-one derivatives as potential tryptophanyl-tRNA synthetase inhibitors

The rapid emergence of bacterial resistance to antibiotics currently available for treating infectious diseases requires effective antimicrobial agents with new structural profiles and mechanisms of action. Twenty-three thiazolin-4-one derivatives were evaluated for their antibacterial activity by d...

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Bibliographic Details
Main Authors: Anca Stana, Dan C. Vodnar, Gabriel Marc, Daniela Benedec, Brînduşa Tiperciuc, Radu Tamaian, Ovidiu Oniga
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
thiazolin-4-one
antibacterial activity
antioxidant activity
tryptophanyl-trna synthetase
docking
Online Access:http://dx.doi.org/10.1080/14756366.2019.1596086

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