Study on the relationship between the serum VEGF, MMP, MK and recurrence and metastasis after gastric cancer surgery

• Main Authors: Bo Li, Lan Zhou
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2016-05-01
• Series: Journal of Hainan Medical University
• Subjects: Serum; VEGF; MMP; MK; Gastric cancer; Recurrence and metastasis
• Online Access: http://www.hnykdxxb.com/PDF/201609/27.pdf

Objective: To study and investigate the relationship between the serum vascular endothelial growth factor (VEGF), matrix metalloproteinase (MMP), midkine (MK) and recurrence and metastasis after gastric cancer surgery. Methods: A total of 78 patients with recurrence and metastasis after gastric cancer surgery in our hospital from January 212 to June 2015 were selected as Group A, 78 patients without recurrence and metastasis at the same time were selected as Group B and 78 healthy persons were selected as Group C. Then the serum VEGF, MMP and MK levels of the 3 groups were compared. The detection levels of local recurrence, regional lymphatic metastasis and distant metastasis in Group A were also compared, and the relationship between the serum VEGF, MMP, MK and recurrence and metastasis after gastric cancer surgery was analyzed by the Logistic analysis. Results: The serum VEGF, MMP and MK indexes of Group A were all higher than those of Group B and Group C. The levels of Group B and Group C had no significant differences. Meanwhile, in Group A, the detection levels of regional lymphatic metastasis and distant metastasis were all higher than those of patients with local recurrence. According to the Logistic analysis, the above indexes all had close relationship with the recurrence and metastasis after gastric cancer surgery. Conclusions: The serum VEGF, MMP and MK of patients with recurrence and metastasis after gastric cancer surgery show higher expression state, and those indexes all have close relationship with the disease.