Modulating Chemosensitivity of Tumors to Platinum-Based Antitumor Drugs by Transcriptional Regulation of Copper Homeostasis

Modulating Chemosensitivity of Tumors to Platinum-Based Antitumor Drugs by Transcriptional Regulation of Copper Homeostasis

Platinum (Pt)-based antitumor agents have been effective in treating many human malignancies. Drug importing, intracellular shuffling, and exporting—carried out by the high-affinity copper (Cu) transporter (hCtr1), Cu chaperone (Ato x1), and Cu exporters (ATP7A and ATP7B), respectively&...

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Bibliographic Details
Main Authors: Yu-Hsuan Lai, Chin Kuo, Macus Tien Kuo, Helen H. W. Chen
Format: Article
Language:English
Published: MDPI AG 2018-05-01
Series:International Journal of Molecular Sciences
Subjects:
high-affinity copper transporter
hCtr1
Sp1
cisplatin
ovarian cancers
drug-resistance
Online Access:http://www.mdpi.com/1422-0067/19/5/1486

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